acute myeloid leukemia (aml-m7) is a type of pediatric aml accounting for 3–10% of primary childhood aml and children may present with a broad variety of symptoms including low-grade fever, diarrhea, easy bruising, failure to gain weight and life-threatening conditions. we report a rare case of aml .a 26-month-old boy who presented with weakness and fatigue. he was diagnosed as a case of amlm-7...

background: anti-hla-antibodies are known to affect the allograft survival in transplant recipient patients. objective: the aim of this study was to evaluate the association between anti-hla antibodies and kidney allograft outcomes, particularly in recipients with concur-rent donor bone marrow cell infusion (dbmi). methods: between june 2006 and may 2007, forty living unrelated donor kidney tra...

AIMS To determine the distribution of tenascin in normal and pathological bone marrow. METHODS 48 different bone marrow lesions were studied immunohistochemically using a monoclonal antibody to tenascin. RESULTS Tenascin immunoreactivity was found in lesions with increased fibrosis and high numbers of reticular fibres. The strongest immunoreactivity was found in myelofibrosis. Bone marrow f...

Factors in the synovial fluid that maintain healthy articular cartilage, such as hyaluronic acid and lubricin, come from above. Is it possible that factors which lead to the destruction of cartilage come from below in the subchondral bone? The recent acquisition of tools to probe early events in osteoarthritis is shedding new light on possible contributions from this compartment on the initiati...

1. Duncker CM, Carrio 1, Berna L, et al. Radioimmune imaging of bone marrow in patients with suspected bone metastases from primary breast cancer. J Nucl Med 1990:31:1450-1455. 2. Bourgeois P, Demonceau G, Stegen M, Ferremans W. 99mTCHM-PAO labeled leucocytes for bone marrow scintigraphy and evaluation of skeletal lesions? Comparison to 99mTc-HSA colloids results. Nucl Med Comm 1990: in press. ...

RATIONALE Nuclear receptor Nur77, also known as NR4A1, TR3, or NGFI-B, is expressed in human atherosclerotic lesions in macrophages, endothelial cells, T cells and smooth muscle cells. Macrophages play a critical role in atherosclerosis and the function of Nur77 in lesion macrophages has not yet been investigated. OBJECTIVE This study aims to delineate the function of Nur77 in macrophages and...

A 76-year-old man with symptomatic bone metastases from castration-resistant prostate cancer underwent Radium-223-dichloride (Ra-223) therapy. Before Ra-223 therapy, he had normal peripheral blood cell counts. Ra-223 therapy relieved his shoulder and low back pain. The elevation of the serum prostate-specific antigen (PSA), doubling every month during Ra-223 therapy, suggested a PSA flare or re...

We studied eight patients with miliary tuberculosis (TB). In all instances, tuberculomatous lesions were demonstrated in the aspirated bone marrow. We conclude that the bone marrow aspiration has great value in diagnosing miliary TB because it provides sufficient material to permit examination of serial sections as needed to confirm the diagnosis. The bone marrow aspiration also is safer than t...