sunitinib is an oral tyrosine kinase inhibitor which prevents tumor growth and metastatic progression. it was approved for treatment of advanced renal cell cancer, gastrointestinal stromal tumor and advanced pancreatic neuroendocrine tumors. it has several adverse reactions on multi organ systems including hematologic system. although the neutropenia and thrombocytopenia commonly happens as gra...

Leebeek FW. Myeloproliferative disease in the pathogenesis and survival of Budd-Chiari syndrome. Haematologica 2006;91: 1712-3. 3. Valla D, Dhumeaux D, Babany G, et al. Hepatic vein thrombosis in paroxysmal nocturnal hemoglobinuria. A spectrum from asymptomatic occlusion of hepatic venules to fatal Budd-Chiari syndrome. Gastroenterology 1987;93:569-75. 4. Hillmen P, Lewis SM, Bessler M, Luzzatt...

By R. DOROTHY SUNDBERG, PH.D., AND RUTH E. HODGSON, M.S. I NTEREST in obtaining specimens of bone marrow comparable to those aspirated from the human sternum, ilium, or spinous process caused us to devise a technic which we feel is both simple and reliable. Many similar technics have been described, but most of them have not attained wide usage because they have required minor surgical operatio...

Introduction Marrow biopsy by surgical trephine is an older procedure than needle aspiration. It is only since the late 1950s that core needle biopsy of the bone marrow has been widely used. Since that time, it has had a considerable effect on diagnostic haematology, pathology and oncology. Wide acceptance is associated with the introduction of a simple procedure using the Jamshidi needle to im...

BACKGROUND Beliefs of caregivers about patient's pain have been shown to influence assessment and treatment of children's pain, now considered an essential part of cancer treatment. Painful procedures in hematology-oncology are frequently referred by children as the most painful experiences during illness. Aim of this study was to evaluate professionals' beliefs about painfulness of invasive pr...

Background: Thrombocytopenia is commonly encountered in a wide range of haematological and non-haematological disorders. Bone marrow examination plays a major role in diagnosis. Aims: The aim of our study was to analyse the etiology and to study megakaryocytic series in different cases of thrombocytopenia, irrespective of age or sex. Methods: This prospective bone marrow aspiration study was do...

INTRODUCTION Bone marrow aspiration (BMA) is a common and useful investigation tool in clinical practice to obtain information about both hematological and non-hematological disorders. The aim of the work was to identify the main indications for BMA in Atbara city, north Sudan and to determine the common diagnoses encountered. METHODS All reports of BMA carried out during a 6-year period from...