Total endothelial destruction results in the exposure of sub-endothelial collagen fibers causing platelet aggregation, adherence, and release of platelet-related factors. This series of events initiates the intrinsic pathway of blood coagulation by activating factor XII. Ideally, sclerosing solutions otherwise should not cause activation or release of thromboplastic activity because this would ...

During blood coagulation ultrastructural lesions were produced on the platelet membrane. They were dependent on the presence of both thrombin and complement (C) and were morphologically identical to the C-dependent ultrastructural lesions (type II) seen in red cells subsequent to activation of C by the alternate mechanismmthough similar in shape they differed in size from ultrastructural lesion...

Coagulation assays currently employed are often low throughput, require specialized equipment and/or require large blood/plasma samples. This study describes the development, optimization and early application of a generic low-volume and high-throughput screening (HTS) assay for coagulation activity. The assay is a time-course spectrophotometric measurement which kinetically measures the clotti...

JOSEPH F. Ross, M.D., Editor

thrombophilia is a pathological state of increased blood coagulability. it causes problems during pregnancy including preeclampsia, stillbirth, repeated abortions, and detached pair. out of the most prevalent factors causing inherited thrombophilia, protein s (prs), protein c (prc), and antithrombin iii (atiii) deficiency, and factor v leiden (fvl) mutation could be mentioned. this study aimed ...

BACKGROUND Propylthiouracil is the most common drug used to treat hyperthyroidism. However, this drug could cause a severe disease, antineutrophilic cytoplasmic antibody-associated vasculitis (AAV), which was usually misdiagnosed. METHODS We reported a 60-year-old woman of propylthiouracil-induced AAV manifested as blood coagulation disorders. The patient was admitted because of hyperthyroidi...

enhanced immune cell trafficking into the central nervous system (cns) and disruption of the blood brain barrier are pathophysiological hallmarks of neuroinflammatory disorders like multiple sclerosis (ms) and its animal model, experimental autoimmune encephalomyelitis (eae). however, recent studies suggest that the coagulation and the contact-kinin system might also be involved in ms developme...