Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing amitriptyline hydrochloride are reviewed. Its therapeutic uses, its pharmacokinetic properties, the possibility of excipient interactions and reported BE/ bioavailability (BA) problems are also taken into consideration. L...

This article describes the synthesis of silver nanoparticles using the aqueous extract of Alternanthera sessilis as a reducing agent by sonication, espousing green chemistry principles. Biologically synthesized nanoparticle-based drug delivery systems have significant potential in the field of biopharmaceutics due to its smaller size entailing high surface area and synergistic effects of embedd...

Drug design may be considered as an integrated whole approach which essentially involves various steps, namely : chemical synthesis, evaluation for activity-spectrum, toxicological studies, metabolism of the drug, i.e., biotransformation and the study of the various metabolites formed, assay procedures, and lastly galenical formulation and biopharmaceutics. The ‘drug design’ in a broader sense ...

Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing amitriptyline hydrochloride are reviewed. Its therapeutic uses, its pharmacokinetic properties, the possibility of excipient interactions and reported BE/bioavailability (BA) problems are also taken into consideration. Li...

The dissolution rate is the rate-limiting step for Biopharmaceutics Classification System (BCS) class II drugs to enhance their in vivo pharmacokinetic behaviors. There are some factors affecting rate, such as polymorphism, particle size, and crystal habit. In this study, improve pharmacokinetics of sorafenib tosylate (Sor-Tos), a BCS drug, two habits Sor-Tos were prepared. A plate-shaped habit...

The aim of this study was to compare the in vitro dissolution behaviour reference (R) and generic-test (T) medicinal products with non-linear effects model. Mathematical function Weibull, employed as basis for model, coupled MATLABTM simulation software describe release profile active substance. Medicinal selected presented include immediate-release tablets Concor 10 mg Bisoprolol mg, which bel...

Literature data on the properties of chloroquine phosphate, chloroquine sulfate, and chloroquine hydrochloride related to the Biopharmaceutics Classification System (BCS) are reviewed. The available information indicates that these chloroquine salts can be classified as highly soluble and highly permeable, i.e., BCS class I. The qualitative composition of immediate release (IR) tablets containi...

The penguin wing oyster Pteria penguin whole body extract was obtained with different solvents. The whole body extracts were assayed for antibacterial activity using agar well diffusion technique against human pathogens. The extracts derived from acetone and chloroform exhibited broad antibacterial activity. Highest activity was exhibited against Klebsiella pneumoniae (6 mm) and Staphylococcus ...

Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing prednisone are reviewed. Due to insufficient data prednisone cannot be definitively classified according to the current Biopharmaceutics Classification System (BCS) criteria as both the solubility and the permeability of ...