Novel pH-sensitive hydrogels were developed as suitable candidates for carriers in bioMEMS devices as well as for oral delivery of therapeutic peptides and proteins due to their ability to respond to environmental pH change. Macromonomers containing various PEG molecular weights were synthesized and used to prepare P(MAA-g-EG) hydrogels were by photopolymerization. P(MAA-g-EG) hydrogels showed ...

MUMPs (Multi-User MEMS Process) based microchannels made of either glass or polysilicon have been successfully designed, fabricated and tested. The fabrication process used timed wet-chemical etching to selectively etch sacrificial materials with the assistance of etch holes. The prototype glass and polysilicon microchannels have cross-section areas of 70 m×4 m and 70 m×2 m, respectively, and b...

their professional advices and guidance on my research. experience with all kinds of fun. Finally, the author's grateful appreciation goes to his parents whose hardworking spirit and dedication to family have always been a great example for the author. Figure 2-1 Schematic diagram of tilted UV lithography in water medium (left: the experimental setup; right: optical refraction path). Figure 2-5...

Applications of microfluidics and MEMS (micro-electromechanical systems) technology are emerging in many areas of biological and life sciences. Non-contact microdispensing systems for accurate, high-throughput deposition of bioactive fluids can be an enabling technology for these applications. In addition to bioactive fluid dispensing, ink-jet based microdispensing allows integration of feature...

For a long time surgeons and basic scientists have been working together in developing instrumentation to restore function across a diseased human joint. In the quest to achieve their objectives during this long journey, they have developed analytical and experimental methods to quantify various parameters across a normal and a diseased joint, like the hip joint. For example, back in the late 8...

Active protein micropatterns and microarrays made by selective localization are popular candidates for medical diagnostics, such as biosensors, bioMEMS, and basic protein studies. In this paper, we present a simple fabrication process of thick (approximately 20 microm) protein micropatterning using capillary force lithography with bifunctional sol-gel hybrid materials. Because bifunctional sol-...

An integration concept for an implantable biosensor for the continuous monitoring of blood sugar levels is presented. The system architecture is based on technical modules used in cardiovascular implants in order to minimize legal certification efforts for its perspective usage in medical applications. The sensor chip operates via the principle of affinity viscometry, which is realized by a ful...

Title of Dissertation: ASSEMBLY OF QUORUM SENSING PATHWAY ENZYMES ONTO PATTERNED MICROFABRICATED DEVICES Angela T. Lewandowski, Doctor of Philosophy, 2007 Directed By: Professor William E. Bentley, Department of Chemical and Biomolecular Engineering I report patterned protein assembly onto microfabricated devices using our unique assembly approach. This approach is based on electrodeposition of...

In this paper, we present a new impedance-based method to detect viable spores by electrically detecting their germination in real time within microfluidic biochips. We used Bacillus anthracis Sterne spores as the model organism. During germination, the spores release polar and ionic chemicals, such as dipicolinic acid (DPA), calcium ions, phosphate ions, and amino acids, which correspondingly ...