Sinapic acid, 3,5-dimethoxyl-4-hydroxycinnamic belonging to the class of hydroxycinnamic acids, shows antioxidant, anti-inflammatory, anticancer, hepatoprotective, cardioprotective, renoprotective, neuroprotective, antidiabetic, anxiolytic, and antibacterial activity. The aim this work was incorporate sinapic acid into solid lipid nanoparticles in order improve its bioavailability. SLNs were pr...

The properties of stable gold (Au) nanoparticle dispersions can be tuned to alter their activity towards biomembrane models. Au coating techniques together with rapid electrochemical screens a phospholipid layer on fabricated mercury (Hg) platinum (Pt) electrode have been used moderate the dispersions. Screening results for were intercalibrated large unilamellar vesicle (LUV) interactions using...

Diosgenin (DGN), which is a sterol occurring in plants of the Dioscorea family, has attracted increasing attention for its various pharmacological activities. DGN structural similarity to cholesterol (Cho). In this study we investigated effects common tetracyclic cores and different side chains on physicochemical properties lipid bilayer membranes. Differential scanning calorimetry showed that ...

Recent advances in atomic force microscopy, biomembrane force probe experiments, and optical tweezers allow one to measure the response of single molecules to mechanical stress with high precision. Such experiments, due to limited spatial resolution, typically access only one single force value in a continuous force profile that characterizes the molecular response along a reaction coordinate. ...

The opioid peptide dynorphin A Biophysical studies of peptide–receptor and peptide–membrane interactions Johannes Björnerås c Johannes Björnerås, Stockholm 2014 Cover layout by c Malin Augustsson: Artist's impression of a biomembrane system. The following papers, referred to in the text by their Roman numerals, are included in this thesis. PAPER I: Direct detection of neuropeptide dynorphin A b...

Quantifying cell-adhesion strength is of great importance in biology and medicine. Cell-adhesion strength can be characterized by separating two adherent cells and determining the force required to do so, or by measuring the lifetime of a receptor-ligand bond that mediates cell adhesion. To this end, several micropipette-based experimental techniques that operate at both cellular and molecular ...

When two binary solutions are separated by a permeable barrier, the individual species typically diffuse and mix, dissipating their chemical potential gradients. However, we use model lattice simulations to show that single-file molecular-sized channels (such biomembrane channels and zeolites) can exhibit diffusional pumping, where one type of particle uses its entropy of mixing to drive anothe...