Biological membranes are involved in numerous intriguing biophysical and biological cellular phenomena of different length scales, ranging from nanoscale raft formation, vesiculation, to microscale shape transformations. With extended length and time scales as compared to atomistic simulations, solvent-free coarse-grained membrane models have been exploited in mesoscopic membrane simulations. I...

Single particle analysis is a tomographic method to reconstruct a three-dimensional structure from a set of two-dimensional projected images acquired by a transmission electron microscope (TEM). This method is applied to reconstruct biological samples such as proteins or viruses. The micrographs of cryo biological samples are obtained by using a minimum dose system (MDS), because these samples ...

Widespread use of silver nanoparticles raises questions of environmental and biological impact. Many synthesis approaches are used to produce pure silver and silver-shell gold-core particles optimized for specific applications. Since both nanoparticles and silver dissolved from the particles may impact the biological response, it is important to understand the physicochemical characteristics al...

The use of charged particle therapy in cancer treatment is growing rapidly, in large part because the exquisite dose localization of charged particles allows for higher radiation doses to be given to tumor tissue while normal tissues are exposed to lower doses and decreased volumes of normal tissues are irradiated. In addition, charged particles heavier than protons have substantial potential c...

Motivated by biological ion channels, we develop a new multiscale method for interacting particle systems coupling a particle and a continuum model. The method aims at the computation of particle interactions on the molecular scale and therefore incorporates particle correlations induced by short and long range interactions. To construct the multiscale method we use a stochastic particle model ...