BACKGROUND Patients in harm-reduction treatment programs are switching from intravenous to other routes of methamphetamine (INN, metamfetamine) administration to avoid risks associated with needle use. Relatively little has been reported about the bioavailability of methamphetamine when smoked or used intranasally. METHODS Eight experienced methamphetamine users were administered smoked or in...

We investigated the effect of calcium carbonate on the oral bioavailability of gemifloxacin. Gemifloxacin was administered alone, 2 h before, simultaneously, or 2 h after calcium carbonate in 16 volunteers. Data for 320 mg of gemifloxacin alone were as follows: maximum concentration of drug in serum (C(max)),13 microg/ml; half-life, 7.33 h; and area under the concentration-time curve from 0 h t...

Three subjects were first given a digoxin tablet in the fasting state and subsequently received the same formulation in the fed state, to simulate a spurious oral bioavailability difference. As expected, when measured by peak serum digoxin concentration as well as by area under the serum digoxin concentration-time curve the bioavailability of digoxin appeared to be higher in the fasting state t...

Recently we have reported anti-TB properties of a new class of conformationally-constrained indeno[2,1-c]quinolines, which are although considerably active (MIC 0.39-0.78 μg/mL) suffered from intense solubility problems. We thought of improving their bioavailability by prodrugs approach. Accordingly esters of the "Lead" indeno[2,1-c]quinolines 1, 15 and 27 derivatives were synthesized and their...

We compared zinc, copper and cadmium concentrations and the operationally defined geochemical partitioning of the three metals in sediments enriched with biofilm versus sediments without obvious biofilm present (reference) sampled from five locations within the Fraser River Delta, British Columbia, Canada. Two-way ANOVA's with site and biofilm (enriched or reference) as the two factors were app...

Stephen Perrett is currently the Corporate Technology Director at Eurand. He is responsible for Merger and Acquisition activities and for the licensing in of new technologies for the Eurand Group. Through internal development and acquisition Eurand now controls one of the broadest ranges of drug delivery technologies in the industry. Dr Perrett has 20 years of experience in the drug delivery in...

BACKGROUND The objective of this study was to develop a novel polydatin (PLD)-loaded liposome system using the thin film hydration technique. METHODS The delivery system was characterized in terms of morphology, size, zeta potential, encapsulation efficiency, and in vitro release. In addition, a pharmacokinetic study was carried out in rats after oral administration of PLD-loaded liposomes in...

iv CHAPTER 1 – THESIS ORGANIZATION AND LITERATURE REVIEW 1 Thesis Organization 1 Abstract 1 Background Entry and detection of antibiotics in the environment 2 Movement and transport of erythromycin in the environment 5 Effects of antibiotics on organisms 8 Potential for the development of bacterial resistance in the environment 10 Problem formulation and research objectives 10 References 12 Fig...