This paper presents a novel unified theory of the structure activity relationship of opioids and opioid peptides. It is hypothesized that a virtual or known heterocyclic ring exists in all opioids which have activity in humans, and this ring occupies relative to the aromatic ring of the drug, approximately the same plane in space as the piperidine ring of morphine. Since the rings of morphine a...

Reaction of Glycin with Malononitrile afforded respective Pyrrole. Pyrrole is one of the heterocyclic compounds with very important biological activities. Heterocycles are extremely important because of their wide range of applications that goes from their use as pharmaceuticals and agrochemicals to dyestuffs and additives. In this view, it was proposed to synthesize pyrrole-3-carbonitrile deri...

Different novel isoxazolines were synthesized by the cyclization of secondary amino derivatives with pyridazine as a substituted intermediate in presence hydroxylamine hydrochloride. Isoxazoline is an important class nitrogen and oxygen-containing five-membered heterocyclic compounds having great medicinal importance. Many heterocyclic, pharmaceutically active have been using it intermediate. D...

The aim of this review is to provide the systematic information synthetic scheme and biological activity synthesized benzimidazole derivatives. Benzimidazole widely used lead molecule for synthesis various types pharmacologically active moiety. It heterocyclic aromatic fused colorless solid having molecular mass 118.053 g/mol. basic in nature can be served as ligand coordination chemistry. bioa...