Prosopis gum (PG) extracted from Prosopis africana was investigated for bioadhesive delivery of theophylline (TPL). Bioadhesive granules containing TPL were formulated and the bioadhesive properties evaluated using adhesion of the granules onto a porcine intestinal mucus surface. The bioadhesion of the gum dispersion was also evaluated using coated glass beads and the strength of the films form...

Inspired by the typically adhesive behaviors of fish skin and Parthenocissus tricuspidata, two different decorations of polystyrene honeycomb membrane (PSHCM) prepared by the breath figure approach were carried out with poly(N-(3-Sulfopropyl)-N-(methacryloxyethyl)-N,N-dimethylammonium betaine)(polySBMA) to explore controllable bioadhesive surfaces. Casting and dip-coating were employed to graft...

Abstract In this work, pure Ti was anodically oxidized using 1M H 3 PO 4 + 2–10 pct HF electrolytes at 10 V vs open circuit potential (OCP). The structure of the anodized samples’ surfaces investigated X-ray diffraction (XRD), photoelectron spectroscopy (XPS), atomic force microscopy (AFM), and scanning electron (SEM). results show presence titanium dioxide (TiO 2 ) hydrogen phosphate (Ti(HPO i...

The present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...

The present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...

The attachment of microorganisms to a surface is a critical first step of biofilm fouling in membrane processes. The shear-induced detachment of baker's yeast in adhesive contact with a plane glass surface was thus experimentally studied, using a specially designed shear stress flow chamber. The yeast was marketed either as rod-shaped pellets (type I yeast) or as spherical pellets (type II yeas...

Aims: Vaginal preparations are still associated with number of problems including frequent administration and escape from vagina causing discomfort to patient. For efficient vaginal delivery of drugs, the delivery system should reside at the site of infection for a prolonged period of time therefore this work aims to prepare Vaginal Capsules containing sustained release in situ forming polymeri...

Fast-gelling chitosan thermosensitive hydrogels have proven to be excellent matrices for targeted drug-delivery and cell therapy. In this work, we demonstrate the possibility of designing injectable bioadhesive with a high gelation rate by modifying catechol (cat-CH) using sodium bicarbonate (SHC) as gelling agent. Cat-CH/SHC gel under 5 min at 37 °C reach secant modulus after 24 h (E = 90 kPa ...

Chitosan is a linear polysaccharide with prominent physicochemical and biological properties such as biocompatibility, biodegradability, nontoxicity, nonimmunogenicity, bioadhesion, antibacterial, antifungal, hemostatic activity. Due to these properties, it has found many applications in cosmetic, textile, food industries; agriculture; biotechnology; pharmaceutical industry medicine, especially...

In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating applications, directly targeting the central nervous system, bypassing the blood brain barrier. Its benefits include dose lowering and direct brain distribution of potent drugs, ultimately reducing systemic side effects. Recently, nasal administration of insulin showed promising results in clinical trials ...