Bioactive peptides in the juxtamembrane regions of proteins are involved in many signaling events. The juxtamembrane regions of cadherins were examined for the identification of bioactive regions. Several peptides spanning the cytoplasmic juxtamembrane regions of E- and N-cadherin were synthesized and assessed for the ability to influence TGFβ responses in epithelial cells at the gene expressio...

The structure of the mouse natriuretic peptide type-B (BNP) gene was determined by isolating and sequencing genomic clones. The mouse BNP gene was structurally similar to other natriuretic peptide genes and comprised three exons and two introns. Expression of the mouse BNP gene was found only in cardiac tissue as determined by ribonuclease protection analyses. Initiation of transcription was 31...

Cationic cell-penetrating peptides (CPPs) have been used widely as delivery vectors for the import of molecules that otherwise do not cross the plasma membrane of eukaryotic cells. In this work, we demonstrate that the three cationic CPPs, Antennapedia homeodomain-derived peptide (Antp), nona-arginine and Tat-derived peptide, inhibit tumour necrosis factor (TNF)-mediated signal transduction. Th...

Abstract Protein-based biologics constitute a rapidly expanding category of therapeutic agents with high target specificity. Their clinical use has dramatically increased in recent years, but administration is largely via injection. Drug delivery across the oral mucosa promising alternative to injections, order avoid gastrointestinal tract and first-pass metabolism. Current drug formulations in...

Abstract Bioactive peptides are currently emerging as nonpharmacological alternatives for treating noncommunicable diseases, including hypertension. Pharmacological treatments hypertension typically involve angiotensin I converting enzyme inhibitors such Captopril and enalapril. This study aimed to evaluate the activity of bioactive derived from food sources against this show its possible mecha...

Spent yeast is one of the main fermentation process by-products and several bioactive ingredients have been extracted from it, such as mannans β-glucans. These extraction processes generate waste streams rich in protein, that can still be used to produce peptide-rich extracts. This work describes use a scalable low-cost obtain peptide extracts circular economy concept. Peptide fractions produce...