نتایج جستجو برای: bim
تعداد نتایج: 6444 فیلتر نتایج به سال:
Background. Building Information Modelling (BIM) has been recently one of the most common issues discussed in publications related to innovative changes in the management of construction projects. The concept of BIM integrates all the activities related to the design, construction and operation into the ICT model developed and implemented within a communication platform. From the point of view ...
EGFR-TKI resistance due to BIM polymorphism can be circumvented in combination with HDAC inhibition.
BIM (BCL2L11) is a BH3-only proapoptotic member of the Bcl-2 protein family. BIM upregulation is required for apoptosis induction by EGF receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) in EGFR-mutant forms of non-small cell lung cancer (NSCLC). Notably, a BIM deletion polymorphism occurs naturally in 12.9% of East Asian individuals, impairing the generation of the proapoptotic isoform req...
the management philosophy, namely, customer relationship management (crm) has been widely accepted and successfully applied across a range of sectors. however, there has been very little research efforts in the field of crm in the construction industry. this paper provides a review of the crm philosophy and technology, and considers the implications benefits and challenges to construction organ...
Chimeric somatostatin/dopamine compounds such as BIM-23A760, an sst2/sst5/D2 receptors-agonist, have emerged as promising new approaches to treat pituitary adenomas. However, information on direct in vitro effects of BIM-23A760 in normal and tumoral pituitaries remains incomplete. The objective of this study was to analyze BIM-23A760 effects on functional parameters (Ca2+ signaling, hormone exp...
Building Information Modelling (BIM) offers the possibility of prototyping building design and construction options in a simulated system, before construction begins, offering the potential for improvements in productivity, product quality and sustainability. In addition, the information resulting from the design and construction process can be transferred for use in the ongoing management and ...
Bim, a BH3-only Bcl-2 family member, is required for apoptosis of thymocytes in response to negative selection signals. Regulation of the apoptotic activity of Bim during negative selection is not understood. In this study we demonstrate that in murine thymocytes undergoing apoptosis in response to anti-CD3epsilon injection, levels of Bim protein expression do not change. In immature thymocytes...
A critical hallmark of cancer cell survival is evasion of apoptosis. This is commonly due to overexpression of anti-apoptotic proteins such as Bcl-2, Bcl-X(L), and Mcl-1, which bind to the BH3 α-helical domain of pro-apoptotic proteins such as Bax, Bak, Bad, and Bim, and inhibit their function. We designed a BH3 α-helical mimetic BH3-M6 that binds to Bcl-X(L) and Mcl-1 and prevents their bindin...
BIM is a proapoptotic protein that initiates apoptosis triggered by EGFR tyrosine kinase inhibitors (TKI). mTOR negatively regulates apoptosis and may influence response to EGFR TKI. We examined mRNA expression of BIM and MTOR in 57 patients with EGFR-mutant NSCLC from the EURTAC trial. Risk of mortality and disease progression was lower in patients with high BIM compared with low/intermediate ...
In the context of Architecture, Building Information Modelling (BIM) is a design methodology which enables all of the design details, decisions and characteristics to be held within a collaborative digital representation and information package. The design and project information can then be shared, accessed and altered live, facilitating an efficient and fluid collaborative design and asset ma...
Apoptosis of vascular cells, including pericytes and endothelial cells, contributes to disease pathogenesis in which vascular rarefaction plays a central role. Bim is a proapoptotic protein that modulates not only apoptosis but also cellular functions such as migration and extracellular matrix (ECM) protein expression. Endothelial cells and pericytes each make a unique contribution to vascular ...
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