In screening for secondary prevention of breast cancer, clinical breast examination (CBE) combined with mammography may improve overall screening sensitivity compared with mammography alone. A systematic evaluation of the relative expenses and projected benefit of combining these two screening modalities is not presently available. We addressed this issue using a microsimulation model incorpora...

1. Stress Granule Modulation by Mammalian Orthoreovirus Factories Promisree Choudhury and Cathy L. Miller Department of Veterinary Microbiology and Preventive Medicine, Iowa State University Phosphorylation of eIF2α induces formation of discrete cytoplasmic inclusions called stress granules (SG). SGs are comprised of translationaly silenced mRNAs, translation initiation factors, ribosomal prote...

Clinical observations have strongly implicated a number of antiseizure agents as human teratogens. The embryopathic potential of three classes of anticonvulsants: oxazolidinediones (OX); hydantoins (Hy), and succinimides (Su) have been evaluated in our laboratory using the CD-1 mouse. Estimated adult lethality curves were used as the basis for selecting doses for teratogenic investigation. Seve...

Further e\ idelice i s prcseiited for the prcsericc of a persistent pcriodicity somewhat in excess of 2 years duration. I t s existence can be shown in the surface temperature a t widely separated stations along two ineridiaiis from Norway t o South Africa and from Canada to Cape Horn. Time series analysis by means of a narrow band-pass filter indicates phase relations among the stations, the m...

The biennial AIDS conference is often exhausting and irritating, but it offers a unique view of how science and society interact. It still deserves the support of basic scientists.