If ∗ : G → G is an involution on the finite group G, then ∗ extends to an involution on the integral group ring Z[G]. In this paper, we consider whether bicyclic units u ∈ Z[G] exist with the property that the group 〈u, u∗〉, generated by u and u∗, is free on the two generators. If this occurs, we say that (u, u∗) is a free bicyclic pair. It turns out that the existence of u depends strongly upo...

We describe the structure of 0-simple countably compact topological inverse semigroups and the structure of congruence-free countably compact topological inverse semigroups. We follow the terminology of [3, 4, 8]. In this paper all topological spaces are Hausdorff. If S is a semigroup then we denote the subset of idempotents of S by E(S). A topological space S that is algebraically a semigroup ...

In this work the results of experimental and computational study of the title compounds and some ancillary compounds are reported. Two bicyclic pyrazol-1,3,4-thiadiazole derivatives were synthesized by reaction between 6-dimethylaminomethylene-3-thioxo-[1,2,4]triazepin-5-one 1 and several nitrilimines 2a-f to give corresponding spirocycloadducts 3a-f, which undergo a rapid rearrangement leading...

Drug discovery pipelines for the "neglected diseases" are now heavily populated with nitroheterocyclic compounds. Recently, the bicyclic nitro-compounds (R)-PA-824, DNDI-VL-2098 and delamanid have been identified as potential candidates for the treatment of visceral leishmaniasis. Using a combination of quantitative proteomics and whole genome sequencing of susceptible and drug-resistant parasi...

Synthesis and structural characterization of a new class of pincer type bicyclic diacyloxy- and diazaselenuranes is reported. The reaction of dimethyl 2-bromo-5-tert-butylisophthalate (28) with sodium benzeneselenolate affords the corresponding monoselenide, dimethyl 5-tert-butyl-2-(phenylselanyl)isophthalate (29). Reduction of 29 with LiAlH(4) provides 5-tert-butyl-2-(phenylselanyl)-1,3-phenyl...

Cyclic peptides have great potential as therapeutic agents and research tools. However, their applications against intracellular targets have been limited, because cyclic peptides are generally impermeable to the cell membrane. It was previously shown that fusion of cyclic peptides with a cyclic cell-penetrating peptide resulted in cell-permeable bicyclic peptides that are proteolytically stabl...

The proprotein convertases are believed to be responsible for the proteolytic maturation of a large number of peptide hormone precursors. Although potent furin inhibitors have been identified, thus far, no small-molecule prohormone convertase 1/3 or prohormone convertase 2 (PC2) inhibitors have been described. After screening 38 small-molecule positional scanning libraries against recombinant m...

Abstract Bicyclic alkenes, including oxa- and azabicyclic readily undergo activation with facial selectivity in the presence of transition-metal complexes. This is due to intrinsic angle strain on carbon–carbon double bonds such unsymmetrical bicyclic systems. During past decades considerable progress has been made area ring opening strained rings by employing concept C–H activation. short revi...