نتایج جستجو برای: bicistronic vector
تعداد نتایج: 197873 فیلتر نتایج به سال:
We describe a strategy for the creation of recombinant ferritin heteropolymers which mimic the natural heterogeneity of this protein. This method entailed the co-expression of cDNA for both ferritin H and ferritin L subunits in a single bacterium using either a bicistronic vector, in which both cDNAs were expressed from the vector, or a dual vector expression strategy, in which each subunit was...
BACKGROUND Involvement of MMP-9, uPAR and cathepsin B in adhesion, migration, invasion, proliferation, metastasis and tumor growth has been well established. In the present study, MMP-9, uPAR and cathepsin B genes were downregulated in glioma xenograft cells using shRNA plasmid constructs and we evaluated the involvement of integrins and changes in their adhesion, migration and invasive potenti...
The human cytomegalovirus (HCMV) open reading frame UL83 encodes a phosphoprotein of 64 to 68kDa (pp65) which is a major constituent of this virion and dense bodies. To determine the importance of the HCMV gene in the virus cycle, we studied HCMV replication in astrocytoma cells stably transfected with a retroviral vector carrying an antisense UL83 cDNA. Reverse transcription-PCR detected antis...
Abstract Chimeric antigen receptor (CAR)-T cells have had a significant effect in hematological diseases, with recent study confirming that the can last for ten years vivo. Unfortunately, to date, CAR-T little solid tumors. One cause of treatment difficulty is antigenic heterogeneity. Our experience glioblastoma suggests addressing heterogeneity may improve clinical efficacy. Targeting epiderma...
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