Our previous dosimetry studies have demonstrated that for dopaminergic radiotracers, (18)F-FDOPA and (18)F-FPCIT, the urinary bladder is the critical organ. As these tracers accumulate in the basal ganglia (BG) with high affinity and long residence times, radiation dose to the BG may become significant, especially in normal control subjects. We have performed dynamic PET measurements using (18)...

Previous studies have demonstrated that bergamottin (BG), a component of grapefruit juice, is a mechanism-based inactivator of CYP3A4 and contributes, in part, to the grapefruit juice-drug interaction. Although the covalent binding of [(14)C]BG to the CYP3A4 apoprotein has been demonstrated by SDS-polyacrylamide gel electrophoresis, the identity of the modified amino acid residue and the reacti...

The DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase (AGT), is inactivated by reaction with the pseudosubstrate, O(6)-benzylguanine (BG). This inactivation sensitizes tumour cells to chemotherapeutic alkylating agents, and BG is aimed at enhancing cancer treatment in clinical trials. Point mutations in a 24 amino acid sequence likely to form the BG-binding pocket were identified using...

OBJECTIVE To examine the impact of maternal blood glucose (BG) level and body mass index (BMI) measured at gestational diabetes mellitus (GDM) screening on the risk of macrosomia. DESIGN A perinatal cohort of women were followed up from receiving perinatal healthcare to giving birth. SETTING Beichen District, Tianjin, China between June 2011 and October 2012. PARTICIPANTS 1951 women aged ...

STUDY DESIGN Disk material removed (DMR) during L4-5 and L5-S1 transforaminal lumbar interbody fusion (T-LIF) surgery was compared to the corresponding bone graft (BG) volumes inserted at the time of fusion. A novel BG delivery tool (BGDT) was used to apply the BG. In order to establish the percentage of DMR during T-LIF, it was compared to DMR during anterior diskectomy (AD). This study was pe...

The moduli space Mg of compact Riemann surfaces of genus g has structure of orbifold and the set of singular points for such orbifold is the branch locus Bg. In this article we present some results related with the topology of Bg, the connectedness of Bg for g ≤ 8, the existence of isolated equisymmetric strata of a given dimension in Bg and finally the connectedness of the branch locus of the ...

This study addresses the hypothesis that the basal ganglia (BG) are involved specifically in the planning of movement amplitude (or covariates). Although often advanced, based on observations that Parkinson's disease (PD) patients exhibit hypokinesia in the absence of significant directional errors, this hypothesis has been challenged by a recent alternative, that parkinsonian hypometria could ...

Background Black ginseng (BG) has greatly enhanced pharmacological activities relative to white or red ginseng. However, the effect and molecular mechanism of BG on muscle growth has not yet been examined. In this study, we investigated whether BG could regulate myoblast differentiation and myotube hypertrophy. Methods BG-treated C2C12 myoblasts were differentiated, followed by immunoblotting...

Gastric emptying (GE) is an important determinant of postprandial blood glucose (BG), yet GE is delayed in anorexia nervosa (AN). This study aimed to characterise relationships between GE (13C-octanoate breath test), and BG responses to, a mixed-nutrient semi-solid meal in 22 female adolescent AN inpatients on admission (BL) and following 1 (W1) and 2 weeks (W2) of refeeding, and in 17 age-matc...