نتایج جستجو برای: beta amyloid

تعداد نتایج: 215549  

Journal: :Journal of Biomedicine and Biotechnology 2006
Deng-Shun Wang Dennis W. Dickson James S. Malter

Extensive beta-amyloid (A beta) deposits in brain parenchyma in the form of senile plaques and in blood vessels in the form of amyloid angiopathy are pathological hallmarks of Alzheimer's disease (AD). The mechanisms underlying A beta deposition remain unclear. Major efforts have focused on A beta production, but there is little to suggest that increased production of A beta plays a role in A b...

Journal: :Nanoscale 2021

Retraction of ‘Size-selected silver nanoparticles for MALDI-TOF mass spectrometry amyloid-beta peptides’ by Feng Ding et al., Nanoscale, 2018, 10, 22044–22054, DOI: 10.1039/C8NR07921H.

Journal: :Biochimica et biophysica acta 2008
Dhandayuthapani Sambasivam Corey W Liu Murali Jayaraman E J Padma Malar Jayakumar Rajadas

Most of the disease causing proteins such as beta amyloid, amylin, and huntingtin protein, which are natively disordered, readily form fibrils consisting of beta-sheet polymers. Though all amyloid fibrils are made up of beta-sheet polymers, not all peptides with predominant beta-sheet content in the native state develop into amyloid fibrils. We hypothesize that stable amyloid like fibril format...

Journal: :Journal of structural biology 2000
S Varadarajan S Yatin M Aksenova D A Butterfield

Alzheimer's disease, the major dementing disorder of the elderly that affects over 4 million Americans, is related to amyloid beta-peptide, the principal component of senile plaques in Alzheimer's disease brain. Oxidative stress, manifested by protein oxidation and lipid peroxidation, among other alterations, is a characteristic of Alzheimer's disease brain. Our laboratory united these two obse...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1994
M P Vitek K Bhattacharya J M Glendening E Stopa H Vlassara R Bucala K Manogue A Cerami

Alzheimer disease (AD) is characterized by deposits of an aggregated 42-amino-acid beta-amyloid peptide (beta AP) in the brain and cerebrovasculature. After a concentration-dependent lag period during in vitro incubations, soluble preparations of synthetic beta AP slowly form fibrillar aggregates that resemble natural amyloid and are measurable by sedimentation and thioflavin T-based fluorescen...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1995
K C Evans E P Berger C G Cho K H Weisgraber P T Lansbury

The apolipoprotein E4 (APOE4) allele is associated with an early age of onset of the nonfamilial form of Alzheimer disease (AD) and with increased beta protein amyloid deposition in the brain. These two observations may both arise from an effect of the apoE family of proteins on the rate of in vivo amyloidogenesis. We report here that apoE3, the common apoE isoform, is an in vitro amyloid nucle...

Journal: :Diabetes 2008
Lucy Marzban Alejandra Tomas Thomas C. Becker Lawrence Rosenberg Jose Oberholzer Paul E. Fraser Philippe A. Halban C. Bruce Verchere

OBJECTIVE Islet amyloid, formed by aggregation of the beta-cell peptide islet amyloid polypeptide (IAPP; amylin), is a pathological characteristic of pancreatic islets in type 2 diabetes. Toxic IAPP aggregates likely contribute to the progressive loss of beta-cells in this disease. We used cultured human islets as an ex vivo model of amyloid formation to investigate whether suppression of proIA...

Journal: :PLoS ONE 2008
Létitia Jean Chiu Fan Lee Michael Shaw David J. Vaux

Polymerization into amyloid fibrils is a crucial step in the pathogenesis of neurodegenerative syndromes. Amyloid assembly is governed by properties of the sequence backbone and specific side-chain interactions, since fibrils from unrelated sequences possess similar structures and morphologies. Therefore, characterization of the structural determinants driving amyloid aggregation is of fundamen...

Journal: :Biochemical Society transactions 2005
R B Parsons B M Austen

Our research has concentrated upon the protein lipid modification of BACE [beta-site amyloid precursor protein cleaving enzyme (beta-secretase)], of which very little is currently known. Lipidation influences the production of Abeta (amyloid beta-protein) by promoting the dimerization of BACE.

Journal: :Neurobiology of aging 1996
T L Tekirian G M Cole M J Russell F Yang D R Wekstein E Patel D A Snowdon W R Markesbery J W Geddes

Immunocytochemistry, using antibodies specific for different carboxy termini of beta-amyloid. A beta 40 and A beta 42(43), was used to compare beta-amyloid deposits in aged animal models to nondemented and demented Alzheimer's disease human cases. Aged beagle dogs exhibit diffuse plaques in the absence of neurofibrillary pathology and the aged polar bear brains contain diffuse plaques and PHF-1...

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