PURPOSE To compare the clinical outcome of different multifocal intraocular lenses (IOLs) based on information reported in the international literature. METHODS All comparative clinical trials that involved implanting at least one multifocal IOL in patients with cataract or presbyopia were extracted from the literature. Clinical outcomes included uncorrected near visual acuity, uncorrected di...

PURPOSE To assess the sensitivity and specificity of predicting refractive error type using information from a four-item questionnaire on the purpose of spectacle use and age at first use. METHODS The Sydney Myopia Study examined 1,740 year 1 (78.9% response) and 2,353 year 7 students (75.3% response) from a random cluster sample of 34 primary and 21 secondary schools across Sydney. Parents o...

PURPOSE To demonstrate the use of the Quality of Life Impact of Refractive Correction (QIRC) questionnaire for comparing the quality of life of pre-presbyopic individuals with refractive correction by spectacles, contact lenses, or refractive surgery. METHODS The 20-item QIRC questionnaire was administered to 104 spectacle wearers, 104 contact lens wearers, and 104 individuals who had undergo...

BACKGROUND The aim of this work was to describe the indications, complications, and outcomes of penetrating keratoplasty (PKP) in Saudi Arabia. METHODS In a retrospective, noncomparative interventional case series, the medical records of patients who underwent PKP from January 2000 to December 2008 and had a minimum follow-up of 6 months were reviewed. All corneas were obtained from eye banks...

OBJECTIVE To compare the relative effectiveness of methotrexate and mycophenolate mofetil for noninfectious intermediate uveitis, posterior uveitis, or panuveitis. DESIGN Multicenter, block-randomized, observer-masked clinical trial. PARTICIPANTS Eighty patients with noninfectious intermediate, posterior, or panuveitis requiring corticosteroid-sparing therapy at Aravind Eye Hospitals in Mad...

OBJECTIVE To evaluate the outcome of phototherapeutic keratectomy (PTK) treatment of epithelial basement membrane dystrophy (EBMD) patients and to examine clinical and morphologic signs of recurrent dystrophy. DESIGN Cross-sectional, clinic-based study. PARTICIPANTS Fifty-two eyes of 39 patients diagnosed with EBMD who underwent PTK between 2001 and 2008. METHODS Preoperative symptoms, be...

Background: Keratoconus, a non-inflammatory corneal ectasia, is reported to have bilateral involvement in over 90% of patients. The purpose of this study was to quantify the extent of asymmetry of disease at presentation to a regional corneal clinic. Methods: Eighty three patients diagnosed at presentation, using a combination of videokeratography, slit lamp examination, and refractive findings...

Recently, a wealth of epigenomic data has been generated by biochemical assays and next-generation sequencing (NGS) technologies. In particular, histone modification data generated by the ENCODE project and other large-scale projects show specific patterns associated with regulatory elements in the human genome. It is important to build a unified statistical model to decipher the patterns of mu...

PURPOSE To evaluate the visual outcome, spectacle independence, and patient satisfaction after implantation of two Acrysof ReSTOR (Alcon Laboratories, Inc., Fort Worth, TX) intraocular lenses (IOLs) with different addition power or their combination in both eyes. METHODS One hundred twenty eyes of 60 patients with bilateral multifocal IOL implantation were divided into three groups of 20 cons...

OBJECTIVE To find a simple means for calculating eye-camera magnification to permit estimation of true retinal object size from a retinal photograph. METHODS The position of the focusing knob on 3 different retinal cameras (TRC-50F and TRC-50X; Topcon America Corp, Paramus, NJ; and the CR6-45NM Non-mydriatic Retinal Camera; Canon Inc, Tokyo, Japan) was measured during optic nerve photography ...