In 1933 Weber and Engelhardt reported the first case of acute pneumonitis due to beryllium poisoning. Other instances of the acute reaction to beryllium salts were described by Van Ordstrand, Hughes, DeNardi, and Carmody (1945). Hardy and Tabershaw (1946) gave details of the chronic or delayed form of the disease, and DeNardi, Van Ordstrand, Curtis, and Zielinski (1953) published a review of 46...

Toxic pulmonary disease from beryllium exposure first came to light in the 1930s, soon after the emergence of industrial uses of beryllium alloys. An early manufacturing application for beryllium compounds, as phosphors in fluorescent tubes, was the cause of some of the first known cases of chronic beryllium disease (CBD) (first termed “pulmonary granulomatosis of beryllium workers”). However, ...

RATIONALE Beryllium continues to have a wide range of industrial applications. Exposure to beryllium can lead to sensitization (BeS) and chronic beryllium disease (CBD). OBJECTIVES The purpose of this statement is to increase awareness and knowledge about beryllium exposure, BeS, and CBD. METHODS Evidence was identified by a search of MEDLINE. The committee then summarized the evidence, dre...

BACKGROUND In this study, we evaluated alternative possibility for CFSE beryllium flow cytometric test against beryllium blood lymphocyte proliferation test (BeLPT) as a standard radioactive clinical screening method to identify sensitization to beryllium. METHODS Delta PD (the ratio of divided cell population to the total number of cells with subtracted counts of unstimulated cells) of speci...

The beryllium lymphocyte transformation test was performed on 16 patients with chronic beryllium disease, 10 subjects (seven patients and three young boys) who were under suspicion, and 117 healthy beryllium workers. The tests gave a positive response in all patients with definite disease and a negative response in the suspected group. Two of the healthy workers had a positive response, indicat...

PURPOSE The debonding load of heat-activated polymethylmethacrylate (PMMA) denture base resin material to a nickel-chromium-beryllium (Ni-Cr-Be) alloy conditioned by three different surface treatments and utilizing two different commercial bonding systems was investigated. MATERIALS AND METHODS Denture resin (Lucitone-199) was bonded to Ni-Cr-Be alloy specimens treated with Metal Primer II, t...

compared with those ofboth the general population and a cohort of viscose-rayon workers. Ratios of observed to expected deaths for lung cancer in the two industrial populations (65 observed) were found to be elevated in both comparisons (1.4 in respect of both the general population (95% confidence interval (CI), 1. 1 1.8) and the viscose-rayon workers (1.0-2.0)) and tended to be concentrated i...

We present the first detection of beryllium in two turnoff stars of the old, metal-poor globular cluster NGC 6397. The beryllium lines are clearly detected and we determine a mean beryllium abundance of log(Be/H)= −12.35± 0.2. The beryllium abundance is very similar to that of field stars of similar Fe content. We interpret the beryllium abundance observed as the result of primary spallation of...

Chronic beryllium disease (CBD) begins as a sensitizing cell-mediated immune response to beryllium antigen that progresses to granulomatous lung disease. Previous studies demonstrated the involvement of proinflammatory cytokines in the disease process, but the pattern and regulation of cytokine release is unknown. Using bronchoalveolar lavage (BAL) cells from CBD patients in short-term tissue c...