Aryl hydrocarbon hydroxylase is a microsomal mixed function oxygenase induced by benz[a]anthracene and other polycyclic hydrocarbons in mammalian cell culture. Actinomycin D or Z-mercapto-1-(/3-4-pyridethyl)benzimidazole (inhibitors of RNA synthesis) or cycloheximide or puromycin (inhibitors of protein synthesis), added simultaneously with benz[a]anthracene, completely prevents aryl hydrocarbon...

Synthesizing azoles from ortho-substituted anilines, CO2 and H2 has proved difficult due to the low nucleophilicity of which hinders their N-formylation, i.e., first step reaction. Herein, we demonstrate that R3SnX Lewis acids (LA), N-methylmorpholine (NMM) or DBU polyethyleneimine (PEI) N-formylmorpholine efficiently catalyse synthesis benzimidazole other by reductive coupling nucleophilic ami...

The often time-consuming and challenging multi-step synthesis of ligands for metal-organic cages is a limiting factor the discovery application new cages. We report highly efficient copper-free one-pot Sonogashira-type coupling preparation symmetric diarylalkyne on both small large scale; bipyridine- benzimidazole-based self-assembly Co4L6 were synthesized in short reaction times high isolated ...

Wehave recently found that 2,5,6-trichloroH~-D-ribofuranosyl)benzimidazole(TCRB) and the corresponding 2-bromo analog have better in vitro activities against HCMV than the clinically used agents ganciclovir and foscarnet, These benzimidazole nucleosides act by a unique mechanism, however, their biological target has not been completely identified. As an approach to probing the target, we have d...

The resistance of gastro-intestinal nematodes of small ruminants (sheep and goat) to benzimidazole anthelmintic drugs seems to be linked primarily to a single mutation in the isotype 1 b-tubulin gene. This study was carried out to investigate the origin and diversity of benzimidazole-resistance alleles in trichostrongylid nematodes. We sequenced a 550 bp fragment of the isotype 1 b-tubulin gene...