Abstract Ten benzimidazole chalcone derivatives were synthesized, and their monoamine oxidase (MAO) inhibitory activity was evaluated. Most compounds showed higher against MAO-B than MAO-A. Compound BCH2 exhibited an IC 50 value of 0.80 μM, thereby showing the most potent inhibition amongst all. In addition, highest selectivity index (SI) with SI 44.11 compared to Among substituents, halogen gr...

A number of novel benzimidazole derivatives 1-4 were synthesized and the catalytic activity of these compounds in a catalytic system consisting of a benzimidazolium salt/Pd(OAc)2/K2CO3 were investigated in the Suzuki-Miyaura and Ullmann type homocoupling reactions under microwave irradiation. We obtained both cross coupling and homocoupling products of pyridine and some side products such as di...

Sunscreens reduce the occurrence risk of skin disorders such as sunburn, aging, and cancer through their ability to absorb, reflect, scatter ultraviolet (UV) radiation. This review provides an overview UV filters active ingredients sunscreen products, emphasizing classification structural characteristics. Their photostability, mechanism action radiation absorption, optical properties, regulator...

The synthesis of benzimidazoles by intermolecular cyclization reaction of 2-iodoanilines with nitriles has been developed. These reactions proceeded without the aid of any transition metals or ligands and just using KOBu(t) as the base. A variety of substituted benzimidazole derivatives can be synthesized by the approach.

Novel benzimidazolo indane-1, 3-dione derivatives were synthesized and characterized by IR, HNMRand Mass spectral analysis. Biological screening of synthesized compounds allowed the identification of some novelanthelmintic agents bearing indane-1, 3-dione and benzimidazole scaffolds. Some of these compounds exhibited promisinganthelmintic activities.

Benzimidazole derivatives, especially 2-phenylbenzimidazole with various substituents on the C-5, C-2 and C-6 positions, are so important in pharmaceutical chemistry. Multiple linear regression was applied to predict activity of 27 novel derivatives as anticancer agents. At first, we made an effort create a QSAR model for selected series density functional theory molecular docking descriptors. ...