Animal models have been used in understanding the neuro-biological basis of depression and predicting successful treatment strategies. The current study focused on two genetic models of depression, the Flinder's Sensitive Line (FSL) and Wister-Kyoto (WKY). Our laboratory showed depressive symptomatology in pre-pubertal WKY and FSL rats, and the current study focused on the strains' anxiety-like...

Recent commentaries have proposed conceptualizations of rumination in terms of both cognitive and behavioral avoidance. This study examined the relationship between rumination, avoidance and depression using a newly developed self-report measure of avoidance in depression, the Cognitive-Behavioral Avoidance Scale (CBAS) [Ottenbreit, N.D., & Dobson, K.S. (2004). Avoidance and depression: The con...

OBJECTIVE To review the literature on the co-occurrence of anxiety with depressive disorders and the rationale for and use of combination treatment with benzodiazepines and selective serotonin reuptake inhibitors/serotonin-norepinephrine reuptake inhibitors (SSRIs/SNRIs) for treating comorbid anxiety and depression. DATA SOURCES PubMed and PsycINFO were searched using terms identified as rele...

background: celiac disease (cd) has an autoimmune disease in response to ingestion of foods containing gluten sausing damage to the mucosal tissue of small intestine. the disease can severely affect quality of life. this study aims to assess the relationship between behavioral disorders and quality of life (qol) in patients with celiac disease. materials and methods: 87 celiac patients and 100 ...

OBJECTIVE Attention deficit hyperactivity disorder is a heterogeneous disorder of unknown etiology. Little is known about the comorbidity of this disorder with disorders other than conduct. Therefore, the authors made a systematic search of the psychiatric and psychological literature for empirical studies dealing with the comorbidity of attention deficit hyperactivity disorder with other disor...

background: the present study investigated the effects of gallic acid (ga) administration on trimethyltin chloride (tmt) induced anxiety, depression, and hippocampal neurodegeneration in rats. materials and methods: in this experimental study, the rats received intraperitoneal (i.p.) injections of tmt (8 mg/kg). the animals received either ga (50, 100 and 150 mg/kg) or saline as the vehicle for...

background: anxiety disorders and substance abuse are commonest comorbidities among bipolar i disorder (bid) patients. this study investigated the prevalence of anxiety disorders among bid patients based on their dependency on opioid. methods: in this cross sectional study the bid patients in iranian hospital of psychiatry were divided into two 89-patient groups; one group was considered as opi...

Improving Outcomes Anxiety disorders have been the neglected stepchild of primary care–based mental health care. Compared with the extensive research in primary care on the adverse effects of depression on somatic symptom burden, decrements in function, and medical utilization and costs (1, 2), far less research has been completed on anxiety disorders. Yet, the National Comorbidity Survey (3) h...

BACKGROUND Environmental and genetic factors contribute to variation in irritable bowel syndrome (IBS), anxiety and depression. Comorbidity between these disorders is high. A previous investigation of our population-based twin cohort revealed that low birth weight increased the risk for development of IBS, with environmental influences in utero as the most relevant contributing factor. We hypot...