Patients with resistant hypertension present high prevalence of a non-dipper blood pressure pattern. Recent results indicate that non-dipping is related partly to the absence of 24-hour therapeutic coverage in patients treated with single morning doses. Accordingly, we investigated the impact of treatment time on the blood pressure pattern in 700 patients with resistant hypertension on the basi...

The effectiveness of antacid maintenance therapy in preventing duodenal ulcer (DU) relapse was investigated. Two hundred and fifty one asymptomatic patients with healed DU were stratified into smokers and non-smokers and randomised to receive for one year either placebo, or Maalox TC three tablets (81 mmol) at bedtime (hs), or Maalox TC three tablets in the morning plus three tablets at bedtime...

Continuous recordings of night time rectal temperature were made at regular intervals over the first six months of life in 49 babies. In the first two weeks of life rectal temperature changed little overnight, but by 6 weeks of age rectal temperature at bedtime was significantly higher than later in the night. By around 12 weeks of age sleeping deep body temperature fell below 36.5 degrees C, a...

H ermida et al. (1) have recently shown an impressive reduction of asleep blood pressure and associated reduction of cardiovascular disease (CVD) events in type 2 diabetic patients treated with at least one antihypertensive drug at bedtime compared with patients who ingested all drugs in the morning. This is a subgroup analysis of the diabetic patients (20%) enrolled in the MAPEC (Monitorizació...

Studies have shown that aspirin may decrease blood pressure when given at bedtime but not when administered on awakening. However, until now, a biologically plausible mechanism of this striking phenomenon was not revealed. We investigated the effect of 100 mg of aspirin administered at bedtime compared with administration on awakening on plasma renin activity and aldosterone levels over 24 hour...

2) Endefen: I consider Endefen to be one of the most valuable weapons in my arsenal against GERD. Usually, I’m wary of multi-ingredient supplements for GI problems because of the potential for intolerance of one or another of the constituents, but the formulators of Endefen seem to have gotten it just right. It’s a powder that dissolves in water, creating a gloppy mix that coats the esophageal ...

Previous research has indicated the need to use large samples in different cultural contexts in order to clarify age and gender differences on morningness-eveningness and sleep habits. The goal of our research was to study the relationship between morningness-eveningness and sleep habits in a large sample of 2,649 adolescents between 12 and 16 years. The Morningness- Eveningness Scale for Child...

Abstract Introduction Psychological distress has been associated with sleep problems. Emerging evidence suggests positive psychological well-being is better sleep. However, most of these studies are cross-sectional and do not provide information on the effect that changes in outcomes have The aim this secondary analysis was to test whether following a 7-week intervention improve mental health w...

OBJECTIVE We prospectively investigated in hypertensive patients with type 2 diabetes if bedtime treatment with ≥1 hypertension medications exerts better blood pressure control and cardiovascular risk reduction than conventional therapy, in which all medications are ingested in the morning. RESEARCH DESIGN AND METHODS We conducted a prospective, randomized, open-label, blinded end point trial...