Fluorescence imaging of amyloid beta (Aβ) polypeptide using a small-molecule fluorophore is practical system for Alzheimer's disease (AD) diagnosis in clinical and research fields. Herein, molecular designing strategy new fluorogenic probe that equips bathochromic emission shift enhanced binding affinity toward Aβ fibril through structural optimization suggested. Thioflavin T (ThT)-derived fluo...

Anthocyanin colors and factors which stabilize and enhance these labile pigments were studied in this thesis. Berry anthocyanin colors were successfully improved by phenolic acid and natural plant extract addition. The results obtained contribute to the understanding of the chemical behavior of anthocyanins. The color quality of black currant wine was improved by the addition of crowberry juice...

We developed three types of film-type stimuli-responsive polymers based on aza-substituted conjugated involving azobenzene, N_bith, N_fluo and Schiff base moieties, C_bith. All polymer films showed bathochromic shifts in absorption spectra followed by chromic behaviors fuming trifluoroacetic acid (TFA). In particular, we disclosed that there were significant differences detecting ability betwee...

of the S, state in place of the second C, value in eq 9. Note that the first C, value must be that of the So state since the distribution of the CF3H molecule is the same as that in the ground state duing the light absorption. In this way, the stabilization energy in the SI state during the light absorption is calculated to be 904 cm-]. With these values, the bathochromic shift due to the compl...

The ever increasing importance of physical methods in the elucidation of the structure and configuration of carotenoids is reviewed. The use of solvent partition, chromatography, X-ray crystallography, infra-red spectroscopy and optical rotary dispersion are briefly discussed. Special emphasis is given to the application of absorption spectroscopy and to 220 MHz proton magnetic resonance spectr...

The synthesis, photophysical properties and electronic structure of seven new chlorin dyads associated benchmark monomers are described. Each dyad contains two identical chlorins linked at the macrocycle [Formula: see text]-pyrrole 13-position. extent communication between constituents depends on nature conjugated linker. is assessed by modification prominent ground-state absorption redox prope...

Four novel receptors were designed and synthesized for colorimetric detection of F− ions. The introduction of four electron withdrawing groups into the backbone of the receptors makes the two phenolic groups efficient hydrogen bonding sites. The binding properties of receptors with anions were examined for the first time by UV–Vis, 1H NMR and fluorescence spectroscopies. The addition of F− resu...

The pathological origin of Alzheimer’s disease (AD) remains uncharted terrain, despite intensive investigation. Discriminating aberrant proteinaceous deposits, such as ?-amyloid (A?) and (hyperphosphorylated) tau protein by imaging methods, is a vital tool to support investigations towards the network interacting features that results in AD pathology. In this context, multispectral fluorescence...