BACKGROUND Parkinson's disease (PD) is accompanied by dysfunctions in a variety of cognitive processes. One of these is error processing, which depends upon phasic decreases of medial prefrontal dopaminergic activity. Until now, there is no study evaluating these processes in newly diagnosed, untreated patients with PD ("de novo PD"). METHODOLOGY/PRINCIPAL FINDINGS Here we report large change...

We report acute onset quadriplegia in a ten year old boy associated with basal ganglia lesions due to biotin deficiency. Prolonged raw egg consumption was identified as predisposing factor for biotin deficiency. Treatment with biotin resulted in remarkable recovery.

The authors report the case of a woman with a right basal ganglia lesion and severe mental-rotation impairments. She had no difficulty recognizing rotated objects and had intact left-right orientation in egocentric space but was unable to map the left and right sides of external objects to her egocentric reference frame. This study indicates that the right basal ganglia may be critical componen...

A crucial step in timing research is to isolate clock components from other sources of temporal variability. Significant progress has been made both behaviorally and neurologically, using elaborate experimental designs that separate timing mechanisms from motoric sensory and mnemonic processes. Marked similarities between the temporal characteristics of the clock in perception and production ta...

We quantified vascular changes in the frontal lobe and basal ganglia of four inherited small vessel diseases (SVDs) including cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), pontine autosomal dominant microangiopathy and leukoencephalopathy (PADMAL), hereditary multi-infarct dementia of Swedish type (Swedish hMID), and hereditary endotheliop...

OBJECT The localization of any given target in the brain has become a challenging issue because of the increased use of deep brain stimulation to treat Parkinson disease, dystonia, and nonmotor diseases (for example, Tourette syndrome, obsessive compulsive disorders, and depression). The aim of this study was to develop an automated method of adapting an atlas of the human basal ganglia to the ...

Asterixis, firstly described in metabolic encephalopathies, may occur unilaterally in patients with various focal brain diseases. Although hardly localizing, most reported cases have showed a contralateral thalamic pathology; but Lesions in the medial frontal lobe, parietal lobe, brain stem, basal ganglia, insular lesions, may also cause unilateral asterixis. In this article, three cases of acu...

The current model of basal ganglia circuits has been introduced almost two decades ago and has settled the basis for our understanding of basal ganglia physiology and movement disorders. Although many questions are yet to be answered, several efforts have been recently made to shed new light on basal ganglia function. The traditional concept of "direct" and "indirect" pathways, obtained from ax...

The "basal ganglia" refers to a group of subcortical nuclei responsible primarily for motor control, as well as other roles such as motor learning, executive functions and behaviors, and emotions. Proposed more than two decades ago, the classical basal ganglia model shows how information flows through the basal ganglia back to the cortex through two pathways with opposing effects for the proper...

The basal ganglia are a group of interconnected subcortical nuclei that represent one of the brain's fundamental processing units. In humans basal ganglia dysfunctions have been associated with numerous debilitating conditions, including Parkinson's disease. To appreciate fully how complicated systems can malfunction, it may first be necessary to understand how such networks work normally. The ...