نتایج جستجو برای: barrel

تعداد نتایج: 6652  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
V Rema M Armstrong-James F F Ebner

The effect of blocking NMDA glutamate receptors in adult rat cortex on experience-dependent synaptic plasticity of barrel cortex neurons was studied by infusing D-AP5 with an osmotic minipump over barrel cortex for 5 d of novel sensory experience. In acute pilot studies, 500 microM D-AP5 was shown to specifically suppress NMDA receptor (NMDAR)-dependent responses of single cells in cortical lay...

2017
Yingcai Song Bing Zhang Fei Guo Maojun Yang Yang Li Zhi-Qiang Liu

The mechanosensitive channel of small conductance (MscS) is a bacterial membrane pore that senses membrane tension and protects cells from lysis by releasing osmolytes. MscS is a homoheptameric channel with a cytoplasmic domain with seven portals and a β-barrel opening to the cytoplasm. TtMscS, an MscS channel from Thermoanaerobacter tengcongensis, is an anion-selective channel. A previous stud...

2014
Wenqing Shi Yuhan Zeng Cheng Zhu Yucheng Xiao Theodore R Cummins Jianghui Hou Lane A Baker

Integration of dual-barrel membrane patch-ion channel probes (MP-ICPs) to scanning ion conductance microscopy (SICM) holds promise of providing a revolutionized approach of spatially resolved chemical sensing. A series of experiments are performed to further the understanding of the system and to answer some fundamental questions, in preparation for future developments of this approach. First, ...

2001
J. A. Silverman

The (bya)8 barrel is the most commonly occurring fold among protein catalysts. To lay a groundwork for engineering novel barrel proteins, we investigated the amino acid sequence restrictions at 182 structural positions of the prototypical (bya)8 barrel enzyme triosephosphate isomerase. Using combinatorial mutagenesis and functional selection, we find that turn sequences, a-helix capping and sto...

Journal: :Biophysical journal 2016
Patrick J Fleming Dhilon S Patel Emilia L Wu Yifei Qi Min Sun Yeom Marcelo Carlos Sousa Karen G Fleming Wonpil Im

The outer membrane of Gram-negative bacteria is an asymmetric membrane with lipopolysaccharides on the external leaflet and phospholipids on the periplasmic leaflet. This outer membrane contains mainly β-barrel transmembrane proteins and lipidated periplasmic proteins (lipoproteins). The multisubunit protein β-barrel assembly machine (BAM) catalyzes the insertion and folding of the β-barrel pro...

Journal: :Symmetry 2012
Undine Leopold

This paper describes 4-valent tiling-like structures, called pseudotilings, composed of barrel tiles and apeirogonal pseudotiles in Euclidean 3-space. These (frequently face-to-face) pseudotilings naturally rise in columns above 3-valent plane tilings by convex polygons, such that each column is occupied by stacked congruent barrel tiles or congruent apeirogonal pseudotiles. No physical space i...

2015
Shobha Sharma

This research paper presents highly optimized barrel shifter at 22nm Hi K metal gate strained Si technology node. This barrel shifter is having a unique combination of static and dynamic body bias which gives lowest power delay product. This power delay product is compared with the same circuit at same technology node with static forward biasing at ‘supply/2’ and also with normal reverse substr...

Journal: :Journal of neurophysiology 2013
E E Kwegyir-Afful H T Kyriazi D J Simons

Feedforward inhibition is a common motif of thalamocortical circuits. Strong engagement of inhibitory neurons by thalamic inputs enhances response differentials between preferred and nonpreferred stimuli. In rat whisker-barrel cortex, robustly driven inhibitory barrel neurons establish a brief epoch during which synchronous or near-synchronous thalamic firing produces larger responses to prefer...

Journal: :Journal of neurophysiology 2005
Michael Shoykhet Peter W Land Daniel J Simons

In rats, whisker trimming during development leads to persistent alterations in the function of cortical barrel circuits and to behavioral deficits later in life. Here we examined how whisker trimming begun either at birth (P0) or on postnatal day 12 (P12), around the onset of whisking behavior, affects receptive fields of layer IV barrel neurons. All whiskers on the left face were trimmed for ...

Journal: :Bioinformatics 2012
Cyril F. Reboul Khalid Mahmood James C. Whisstock Michelle A. Dunstone

MOTIVATION The β-barrel is a ubiquitous fold that is deployed to accomplish a wide variety of biological functions including membrane-embedded pores. Key influences of β-barrel lumen diameter include the number of β-strands (n) and the degree of shear (S), the latter value measuring the extent to which the β-sheet is tilted within the β-barrel. Notably, it has previously been reported that the ...

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