Corticosteroids have been proved to be ineffective for Guillain-Barré syndrome, but the mechanism remains unknown. In a rabbit model of axonal Guillain-Barré syndrome, treatment with corticosteroids significantly reduced macrophage infiltration in the spinal ventral roots and the survival rate as well as clinical improvement. On 30(th) day after onset, there was significantly higher frequency o...

A patient with Guillain-Barré syndrome is reported on who responded favourably to a short course treatment with the novel immunosuppressant sodium fusidate (Fucidin), given at a daily dose of 1.5 g for one week. Along with prompt and clear cut clinical improvement, treatment with Fucidin was associated with a rapid decline in the blood concentrations of inflammatory cytokines presumably implica...

Human immunoglobulin is an effective treatment for Guillain-Barré syndrome, although the mechanism of action is not understood. We have investigated the effect of human immunoglobulin in an animal model of Guillain-Barré syndrome, namely experimental autoimmune neuritis (EAN), induced in Lewis rats by immunization with bovine spinal root myelin. Human immunoglobulin administered intraperitoneal...

Guillain-Barré syndrome is a rare condition in pregnancy which is characterised by symmetrical progressive ascending polyneuropathy. A case of a 16-year-old nulliparous woman who presented with rapidly progressive limb paralysis following an upper respiratory tract infection a week prior to presentation is discussed. She was intubated as she had developed respiratory failure and managed in the ...

The discovery of the Guillain-Barré syndrome and related disorders Richard Hughes et al., London, United-Kingdom Pathophysiology of autoimmune polyneuropathies Marinos C. Dalakas, Athens, Greece Diagnosis, treatment and prognosis of Guillain-Barré syndrome (GBS) Pieter A. van Doorn, Rotterdam, The Netherlands Chronic inflammatory demyelinating polyradiculoneuropathy Peter Y.K. Van den Bergh, et...

UNLABELLED We report the case of a pregnant woman presenting with Guillain-Barré syndrome in which her neurologic status worsened immediately after delivery under epidural analgesia. We believe that the anesthetic technique may have played a role in the disease progression. Because of this potential association, the risks of worsening neurologic status after regional anesthesia and alternative ...

We report a case involving a 7-year-old girl who initially presented with seizure and hypertensive encephalopathy, serious autonomic manifestations associated with Guillain-Barré syndrome, followed by subsequent bilateral ascending flaccid paralysis. Cerebrospinal fluid analysis showed cytoalbuminous dissociation. Nerve conduction velocity tests showed features of demyelinating polyradiculoneur...

OBJECTIVE To report eight cases of sensory Guillain-Barré syndrome (GBS). BACKGROUND The concept of sensory equivalent to ascending paralysis of GBS was raised in 1958, and the diagnostic criteria for a sensory loss and areflexia variant of GBS were proposed in 1981. However, clinical cases meeting these criteria have been relatively scarce. METHODS During a 13-year period between 1986 and ...

Guillain-Barré syndrome consists of a group of neuropathic conditions characterized by progressive weakness and diminished or absent myotatic reflexes. The estimated annual incidence in the United States is 1.65 to 1.79 per 100,000 persons. Guillain-Barré syndrome is believed to result from an aberrant immune response that attacks nerve tissue. This response may be triggered by surgery, immuniz...

BACKGROUND The unpredictability of the early course of Guillain-Barré syndrome (GBS) makes it difficult to determine which patients' conditions will worsen under observation. Most large randomized treatment trials for GBS have used an inability to walk as the enrollment criterion. Consequently, little is known about the treatment of those patients with milder degrees of affection. OBJECTIVES ...