Due to its inherent reactivity, nitroxyl (HNO), must be generated in situ through the use of donor compounds, but very few physiologically useful HNO donors exist. Novel N-substituted hydroxylamines with carbon-based leaving groups have been synthesized, and their structures confirmed by X-ray crystallography. These compounds generate HNO under nonenzymatic, physiological conditions, with the r...

PVC/NiFe2O4/Fe2O3 compositewas successfully synthesized and characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), and scanning electron microscopy (SEM). Also, the catalytic activity of PVC/NiFe2O4/Fe2O3 has been considered in the synthesis of two arylidene barbitu...

one-pot multicomponent reaction between isatin, barbituric acid, and 6-amino-1,3-dimethyl uracil was investigated in the presence of sulfonic acid functionalized nanoporous silica (sba-pr-so3h) and resulted in the formation of spirooxindole dipyrimidines. spirooxindole unit is found in many natural products and biologically active molecules and 1,4-dihydropyridines are an important class of com...

The aim of the this study was to have a comparison between Zataria multiflora and Rosemarinus officinalis extractson quality of minced frozen silver carp preserved in cold storage temperature -18°C for six months. In this research, one control and three treatments of minced silver carp were prepared as Tr1 (+ Zataria), Tr2 (+Rosemary) and Tr3 (mixed with Rosemary and Zataria) all in normal pack...

The sodium salt of cyclohexenylmethyl-Nmethyl barbituric acid (evipan sodium) is a comparatively new basal anaesthetic. It is supposed to have the property of inducing surgical anaesthesia for short periods of about 15 to 20 minutes. It has a wide margin of safety and so it has gained considerable popularity as a general anaesthetic in surgical procedures of short duration. Anaesthetics in gene...

The title compound, C25H26Cl2FN3O4S, contains two bio-active moieties (thio-barbituric acid and fluoro-quinolone). In the crystal, mol-ecules are linked via C-H⋯O and C-H⋯F hydrogen bonds, forming two-dimensional slab-like networks lying parallel to the bc plane. The benzene ring substituted by F and Cl atoms and the 4-chloro-butyl group seem to be partly disordered, however attempts to model t...

Fast Reaction Kinetics, Pulse Conductometry, Peroxyl Radicals, Radiation Chemistry The kinetics of the reactions of CO2 + OH -»HCO3 (i) and barbituric acid ^barbiturate anion -jH+ (ii) have been remeasured using as a new approach the pulse radiolysis technique with optical and conductivity detection. The rate constants obtained in the present study, ki (21 °C) = 6900 ± 700 M^s"1 and ku (19 °C) ...

Since the 1864 landmark discovery by Adolf von Baeyer, barbituric acids have played a prominent role in medicine and organic synthesis. The barbituric acid scaffold occurs in more than 5000 pharmacologically active compounds, including commonly used anticonvulsant, hypnotic, and anticancer agents (Figure 1a). Moreover, as an easily accessible feedstock material, it is an extremely useful buildi...