BACKGROUND Arf GAPs are multidomain proteins that function in membrane traffic by inactivating the GTP binding protein Arf1. Numerous Arf GAPs contain a BAR domain, a protein structural element that contributes to membrane traffic by either inducing or sensing membrane curvature. We have examined the role of a putative BAR domain in the function of the Arf GAP ASAP1. RESULTS ASAP1's N terminu...

Endophilin-A1 belongs to the family of BAR domain containing proteins that catalyze membrane remodeling processes via sensing, inducing and stabilizing membrane curvature. We show that the BAR domain of endophilin-A1 binds arachidonic acid and molds its coenzyme A (CoA) activated form, arachidonyl-CoA into a defined structure. We studied low resolution structures of endophilin-A1-BAR and its co...

We consider the nature of orbits near the solar neighborhood which are perturbed by local spiral arms and the Milky Way bar. We present a simplified Hamiltonian model which includes resonant terms from both types of perturbations and is similar to the forced pendulum. Via numerical integration of this model we construct Poincare maps to illustrate the nature and stability of the phase space. We...

Abstract The full-heavy tetraquarks $$cc{\bar{c}}{\bar{b}}$$ c ¯ b and $$bb{\bar{b}}{\bar{c}}$$ are systematically investigated within a quark model. meson–meson structure, diquark–antidiquark structure K-structure considered in...

Vegetation was added to a fully developed sandy point bar in the meander of a constructed stream. Significant changes in the flow structure and bed topography were observed. As expected, the addition of vegetative resistance decreased the depth-averaged streamwise velocity over the bar and increased it in the open region. In addition, the secondary circulation increased in strength but became c...

In this paper, a four-bar mechanism with two flexible links is proposed to be used in a micromechanical flying insect robot wing thorax design for stroke amplification. PZT5H and PZN-PT based unimorph actuators are utilized at the input link of the four-bar. The kinematics and dynamics of the proposed wing strcuture with two parallel four-bar mechanisms are analyzed, and DC forces generated at ...

Multi-tilde-bar operators allow us to extend regular expressions. The associated extended expressions are compatible with the structure of Glushkov automata and they provide a more succinct representation than standard expressions. The aim of this paper is to examine the derivation of multi-tilde-bar expressions. Two types of computation are investigated: Brzozowski derivation and Antimirov der...