BACKGROUND AND OBJECTIVES The objective of this study was to evaluate the risk of Gram-negative bacterial infections in febrile neutropenic patients and to develop a specific risk score. DESIGN AND METHODS This prospective study included 513 consecutive febrile neutropenic, evaluable patients. Forty-five per cent of the patients were receiving prophylactic gut decontamination, and 6% were rec...

BACKGROUND Previous studies of children with temperatures > or = 106 degrees F (hyperpyrexia) disagree as to whether hyperpyrexia confers a high risk of serious bacterial infection. OBJECTIVES The purpose of this study was to determine (1) the risk of serious bacterial infection in children with hyperpyrexia and (2) whether clinical presentation can identify hyperpyrexic patients at risk for ...

In a diet, probiotics and prebiotics play an important role in regulating the immune response function through the intestinal microbiota, which in turn affects the immune system. While probiotics have been shown to reduce diseases, such as the flu, which is a respiratory infection. The National Health Commission of China and the National Bureau of Traditional Medicine of China recommend that pr...

Epithelial cells that line the human intestinal mucosa are the initial site of host invasion by bacterial pathogens. The studies herein define apoptosis as a new category of intestinal epithelial cell response to bacterial infection. Human colon epithelial cells are shown to undergo apoptosis following infection with invasive enteric pathogens, such as Salmonella or enteroinvasive Escherichia c...

to determine the prevalence of bacterial mastitis in cattle, milk samples positive for california mastitistest (cmt) were cultured during a period of almost 4 years. the bacterial species isolated from 2904 milksamples studied were coagulase negative staphylococcus sp. in 879 (30.27%) samples, streptococcusagalactiae in 642 (22.11%), s. dysgalactiae in 332 (11.43%), e. coli in 295 (10.16%), sta...

diarrheal disease is one of the main causes of death in developing countries. this study was performed to the prevalence of bacterial causes of diarrhea in patients admitted to the military hospitals and imam khomeini medical center hospital. this cross-sectional study was conducted in a period of 9 months from june 2014 to february 2015, 435 non-duplicative diarrheal stool samples were collect...

This article provides an overview of developments in approaches to identify novel bacterial components for use in recombinant subunit vaccines. In particular it describes the processes involved in "reverse vaccinology", and some associated complementary technologies such as proteomics that can be used in the identification of new and potentially useful vaccine antigens. Results obtained from th...

1307 patients with suppurative bacterial infections caused by multidrug-resistant bacteria of different species were treated with specific bacteriophages (BP). BP therapy was highly effective; full recovery was noted in 1123 cases (85.9%). In 134 cases (10.9%) transient improvement was observed and only in 50 cases (3.8%) was BP treatment found to be ineffective. The results confirm the high ef...

Since the commercialization and ubiquitous use of antibiotics in the 20th century, there has been a steady increase in the number of reports on resistant bacteria. In recent years, this situation has become even more dramatic. The relatively slow development of new drugs, especially those with novel modes of action on target bacteria, is not paired with the rapid rate of resistance appearance. ...

Brucellosis is one of the major infectious and contagious bacterial diseases in Hinggan League of Inner Mongolia, China. The number of newly infected human brucellosis data in this area has increased dramatically in the last 10 years. In this study, in order to explore effective control and prevention measures we propose a deterministic model to investigate the transmission dynamics of brucello...