Recurrent cystitis and vaginitis are a prominent part of daily medical consultations in urology and gynecology. The difficulty in addressing recurrences with an effective therapeutic strategy is increasingly frustrating, both for patients and physicians. Despite the failure in reducing the aggressiveness of bacterial pathogens especially in the uro-genital tract, there is a limited awareness of...

TRPA1-related drugs alter sensation, particularly in conditions of inflammation. To further characterize the role these bladder TRPA1 agonist cinnamaldehyde (CMA) and oral true cinnamon spice were examined preclinical models pain. Female adult rats, with without acute zymosan-induced cystitis, anesthetized visceromotor (VMR) cystometric responses to urinary distension (UBD) determined following...

Bacterial infection is the most common cause of pyelonephritis. Acute complicated pyelonephritis is an acute emergency and needs immediate treatment with intravenous antibiotics. Infection in acute pyelonephritis is usually due to ascending infection, or due to hematogenous infection. Chronic pyelonephritis is characterized by the presence of recurrent infections, usually due to structural and ...

PURPOSE Interstitial cystitis is a chronic inflammatory disease of the bladder and luminal nitric oxide has been shown to be increased in the bladder in patients with interstitial cystitis. We analyzed endogenous nitric oxide formation and inducible nitric oxide synthase gene expression in the bladder of patients with interstitial cystitis to obtain further knowledge of the localization of indu...

BACKGROUND Cystitis causes considerable neuronal plasticity in the primary afferent pathways. The molecular mechanism and signal transduction underlying cross talk between the inflamed urinary bladder and sensory sensitization has not been investigated. RESULTS In a rat cystitis model induced by cyclophosphamide (CYP) for 48 h, the mRNA and protein levels of the excitatory neurotransmitter ca...

Introduction. Postcoital cystitis is a special form of recurrent cystitis. Against the background this disease, especially with an aggressive course, daily activity patients may change, quality life deteriorate, and sexual dysfunction develop. Aim. Study prevalence in postcoital cystitis, as well to assess their life. Material methods. The study compared two groups patients: main (first group) ...

Emphysematous cystitis is a rare form of infection. Well known symptoms are: dysuria, urinary frequency and lower abdominal pain. We experienced a case of emphysematous cystitis presented with atypical peritoneal sign and computed tomography findings of massive intra-peritoneal fluid collection and abnormal gas appearance in pelvic space. Due to its presentation as acute abdomen, patient underw...

Encrusted cystitis is a subtype of chronic cystitis characterized by multiple calcifications in the form of plaques located in the interstitium of the urinary bladder mucosa and frequently associated with mucosal ulcers. It is a very rare disease of controversial etiology. Our transmission electron microscopy of the calcified plaques of encrusted cystitis has revealed that the smallest formed p...

In cats less than 10 years of age, idiopathic cystitis accounts for clinical signs of irritative voiding in 60 to 70% of cats. Urolithiasis is encountered in 10 to 20% of cases, with most being associated with either calcium oxalate or struvite. About 10% may have an associated structural abnormality such as urachal diverticulum or urethral stricture, another 10% have what appears to be a behav...

Changes in the indigenous vaginal microflora with uropathogenic bacteria can predispose women to frequently recurring bacterial cystitis. Lactobacilli used as probiotics have played an important role in preventing the colonization of pathogenic bacteria in the vagina. A prospective clinical pilot study was performed to confirm the safety and effectiveness of Lactobacillus vaginal suppositories ...