The spermatogenesis locus azoospermia factor (AZF) in Yq11 has been delineated into three microdeletion intervals designated as AZFa, AZFb andAZFc. AZFc is the most frequently deleted region. We have studied 270 male infertile patients for various genetic disorders associated with infertile phenotype. In this study, we have presented results of our studies on Y-chromosome deletions, chromosomal...

About 30-40% of male infertility is due to unknown reasons. Genetic contributions to the disruption of spermatogenesis are suggested and amongst the genetic factors studied, Y chromosome microdeletions represent the most common one. Screening for microdeletions in AZFa, b and c region of Y chromosome showed a big variation among different studies. The purpose of this study was to investigate th...

Mất đoạn AZF trên nhiễm sắc thể Y là nguyên nhân gây vô sinh quan trọng ở nam giới. Mối liên giữa mất với nồng độ hormone sản và các đặc điểm lâm sàng bệnh vấn đề cần được làm sáng tỏ. Mục tiêu: khảo sát Y, dục mối một số thiểu tinh tinh. Đối tượng phương pháp nghiên cứu: chúng tôi cứu 161 Kết quả: gặp 15 (chiếm 9,3%), trong đó AZFc hay nhất. Nồng FSH, LH testosterone trung bình lần lượt là: 16...

Abstract Study question To investigate which semen parameter in AZFc microdeletion patients affect the intracytoplasmic sperm injection (ICSI) clinical outcomes. Summary answer AZF-microdeletion caused oligospermia affected ICSI outcome when concentration is less than 1x106/ml. What known already reduce impact of female factors on outcomes, this study employed a propensity score matching analys...

Microdeletions of the azoospermia factor (AZF) regions in the Y chromosome are a well-known genetic cause of male infertility, resulting in impairment of spermatogenesis. However, the partial deletions of AZFc region related to spermatogenetic impairment are controversial. We investigated partial deletion of AZFc region and DAZ copy number in a population of Iranian infertile men and normozoosp...