Natural products are one of the resources for discovering novel pesticide leads. Here, by molecular hybridization between natural enamino diketone skeleton and reported herbicide lead compound I, a series 3-(1-aminoethylidene)-6-methyl-2H-pyran-2,4(3H)-dione derivatives (APD) were rationally designed, synthesized tested herbicidal activity in greenhouse. The bioassay results showed that most ta...