The development of an anterior-posterior (AP) polarity is a crucial process that in the mouse has been very difficult to analyse, because it takes place as the embryo implants within the mother. To overcome this obstacle, we have established an in-vitro culture system that allows us to follow the step-wise development of anterior visceral endoderm (AVE), critical for establishing AP polarity. H...

We evaluated the effect of the nonpeptide mimic of angiotensin (Ang)-(1-7), AVE 0991, on the hypotensive effect of bradykinin (BK). Increasing doses of intra-arterial or intravenous BK were administered before and 30 minutes after the beginning of AVE 0991 infusion. The effect of AVE 0991 on plasma Ang-converting enzyme activity was tested using Hip-His-Leu as the substrate. The interaction of ...

Last Term, the Supreme Court confronted constitutional issues of sex discrimination and search and seizure. First, in Atwater v. City of Lago Vista,1 the Court held that the Fourth Amendment creates no bar to the warrantless arrest of a citizen for a misdemeanor criminal offense. Then, in Nguyen v. INS,2 the Court upheld against an equal protection challenge a statute that imposed different req...

There are several locations within the paper that refer to the incorrect Supporting Information file. The locations of the errors and the correct Supporting Information files are as follows: In the Results and Discussion section, the eighth sentence of the first paragraph under the subheading “Tyramine, octopamine and dopamine evoke complex direct-currents (ID) in OA/TAMac injected oocytes” sho...

Three groups of dogs were given ouabain (mean 60 mug/kg) until an accelerated ventricular escape (AVE) and repetitive ventricular response (RVR) followed cessation of pacing. In a group of six control dogs, the AVE and RVR were found to occur at stable escape intervals for periods of at least three hours. A second group of dogs received various antiarrhythmic agents in an attempt to suppress th...

A novel inertial inverse-free dynamical system is proposed to solve the absolute value equation (AVE). Under mild conditions, model has a unique solution and its trajectories asymptotically converge of AVE. Compared with existing systems, presence term allows new be more convenient for exploring different solutions Numerical results illustrate effectiveness presented method.

The carboxy-terminal domain (CTD) of RNA polymerase II (Pol II) consists of heptad repeats with the consensus motif Y1-S2-P3-T4-S5-P6-S7. Dynamic phosphorylation of the CTD coordinates Pol II progression through the transcription cycle. Here, we use genetic and mass spectrometric approaches to directly detect and map phosphosites along the entire CTD. We confirm phosphorylation of CTD residues ...

I. Supplementary methods and results ........................................................................S1 II. Supplementary figures (5) .......................................................................................S7 III. Supplementary tables (5)........................................................................................S12 IV. Supplementary notes (literature cited) ....

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