• Trastuzumab (Herceptin) directed against the HER-2 receptor and approved for treatment of metastatic breast cancer • Cetuximab (Erbitux) and panitumumab (Vectibix) directed against the epidermal growth factor receptor (EGFR) and approved for treatment of e.g. colorectal cancer • Bevacizumab (avastin) directed against the vascular endothelial growth factor (VEGF) and approved for treatment of ...

Aim: To study the reduction in macular oedema Central Retinal Vein Occlusion cases following Intravitreal injection of Bevacizumab using Spectral Domain Optical Coherence Tomography. Methods: 50 patients diagnosed with more than 300 microns on Tomography ( SD-OCT) ,who attended to Out patient Department Government Regional Eye Hospital (GREH) between January 2020 June were administered Injectio...

For doctors at Memorial Sloan-Kettering Cancer Center in late 2012, it was an easy call. The drug Zaltrap, new on the market (Bach 2012) for treatment of patients with metastatic colorectal cancer, promised to provide an overall survival benefit of 1.4 months compared with a standard chemotherapy regimen. But so did Avastin (bevacizumab) — and the two drugs had similar mechanisms of action, pre...

The most common reason for blindness in developed countries is age-related macular degeneration (AMD) that can be classified into two main categories: the atrophic, or dry form and the exudative, or wet form. The diagnostic difference between dry and wet AMD is the development of choroidal neovascularization in wet AMD. A master regulator in the development of neovascularization is Vascular End...

PURPOSE To evaluate the safety and efficacy of intravitreal injections of bevacizumab (Avastin((R))) as a treatment option for radiation maculopathy secondary to proton beam radiotherapy for choroidal melanoma. CASE A 61-year-old woman presented with a gradual decrease in left eye visual acuity (VA) 29 months after proton beam radiotherapy for choroidal melanoma. On presentation, her best-cor...

Translocation of a nascent protein from the cytosol into the ER mediated by its signal peptide is a critical step in protein secretion. The aim of this work was to develop a platform technology to optimize the signal peptides for high level production of therapeutic antibodies in CHO cells. A database of signal peptides from a large number of human immunoglobulin (Ig) heavy chain (HC) and kappa...

1 = number of abstract – I’ll ask to have CRP added to my monthly bloodtest 2 – I’ll ask to have LDH added to my monthly bloodtest 3 and 4 – Taxotere (docetaxel) + estramustine (3x280 mg/day) better than Taxotere alone 5 – same as 3 and 4, but 3x140 mg/day estramustine equally effective as 3x280 mg, and less toxic 6 – Thalidomide + bevacizumab (Avastin) + Taxotere: works! 7 – Taxotere + Carbopl...