نتایج جستجو برای: avascular osteonecrosis
تعداد نتایج: 8574 فیلتر نتایج به سال:
Mesenchymal stromal cells are multipotent cells capable of tissue repair and immune modulation. They are primarily found in bone marrow, but are also present in other tissues of mesenchymal origin, such as fatty tissue, muscle, tendons, etc. MSC can easily be obtained by bone marrow aspiration, showing a rapid expansion in vitro. New protocols enable cell culture without the use of animal-deriv...
Of the definitions listed in the International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10), two disease descriptions can be found together: "idiopathic aseptic bone necrosis" and "avascular bone necrosis." The relevant literature on both the conditions abbreviates both as "aseptic ischemic osteonecrosis in the jawbone" (AIOJ). To shed light on the...
UNLABELLED Over the past three years, several reports have been published on jaw osteonecrosis possibly being associated with the administration of bisphosphonates. Bisphosphonates are highly active inhibitors of osteoclasts. These drugs are used for the treatment of multiple myeloma, bone resorption in the case of metastatic malignant diseases, tumor-associated hypercalcaemia, and in the treat...
of ONJ [6–8], although such reports in the context of the large phase III trials of these agents are lacking. These reports included patients treated with sunitinib, an inhibitor of the tyrosine kinases of VEGF, PDGF, c-kit, FLT3 and RET, or bevacizumab, a monoclonal antibody, which solely inhibits VEGF. Taken together these reports underline the importance of VEGF in the development of ONJ. Th...
Osteonecrosis and decline of bone density are serious side effects during and after treatment of childhood acute lymphoblastic leukemia. It is unknown whether osteonecrosis and low bone density occur together in the same patients, or whether these two osteogenic side-effects can mutually influence each other's development. Bone density and the incidence of symptomatic osteonecrosis were prospec...
The SARS-CoV-2 (COVID-19) coronavirus pandemic has prompted scientific research. Hypotheses regarding its pathogeneticmechanisms and treatment are formulated, unwanted consequences of the infection determined. Objective. To provideuseful information for clinicians about possible complications from musculoskeletal system after COVID-19 thetimely application effective methods their prevention. Ma...
nitrogen containing bisphosphonate (n-bp) therapy is used extensively to treat osteoporosis and osteolytic bone lesions. recently, a special form of osteonecrosis limited to the maxillofacial skeleton has been discovered especially within those patients who are receiving either long-term n-bp therapy alone and/or associated with invasive dental procedure. bisphosphonates accumulate almost exclu...
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