The cell stress chaperone heat shock protein 90 (Hsp90) has been implicated in inflammatory responses and its inhibition has proven successful in different mouse models of autoimmune diseases, including epidermolysis bullosa acquisita. Here, we investigated expression levels and secretory responses of Hsp90 in patients with bullous pemphigoid (BP), the most common subepidermal autoimmune bliste...

E. Telegdy, I. Schneider, Department of Dermatology, University Medical School, Pécs (Hungary) Sir, The association of cutaneous T cell malignant lymphoma (CTCL) and a vesiculobullous disease is extremely rare. Kaposi [1] in 1887 presented the first report of a pemphigus-like dermal lesion associated with mycosis fungoides. Since then a few associations of CTCL and other autoimmune bullous dise...

Histone deacetylase (HDAC) inhibitors represent a novel class of medication that is being targeted for use in the treatment of cancer. A member of this class, vorinostat, has recently been approved for the therapy of cutaneous T-cell lymphoma. Importantly, emerging data from animal studies have indicated that HDAC inhibitors may have the capacity to potently suppress the development of autoimmu...