Autism spectrum disorder (ASD) is a pervasive developmental disorder which affects a great number of children around the world while the etiology is largely unclear. A hypothesis that autism is an infantile post-trauma stress disorder (PTSD) was proposed in this article based on comparisons of symptoms between ASD and PTSD and the integration of findings on neural basis of autism and the Intens...

OBJECTIVE To summarize recent advances about the nature, diagnosis, and treatment of pervasive developmental disorders. METHOD Review of Medline databases, books, and book chapters published between July 1989 and November 1999. RESULTS Clinical and genetic studies support expansion of the concept of autism to include a broader spectrum of social communication handicaps. The prevalence of au...

Introduction To describe the relationship or lack thereof, between Betaagonist drugs such as terbutaline and autism. Relevant scientific publications regarding autism spectrum disorders were reviewed. The data in both human and animal studies regarding Beta-agonist drugs used for treatment of asthma as well as preterm labour were interrogated for potential association with Autism Spectrum Disor...

Autism is a neurodevelopmental disorder characterized clinically by impairments in social interaction and verbal and non-verbal communication skills as well as restricted interests and repetitive behavior. It has been hypothesized that altered brain environment including an imbalance in neurotrophic support during early development contributes to the pathophysiology of autism. Here we report th...

BACKGROUND Difficulty modeling complex behavioral phenotypes in rodents (e.g., language) has hindered pathophysiological investigation and treatment development for autism spectrum disorders. Recent human neuroimaging studies, however, have identified functional biomarkers that can be more directly related to the abnormal neural dynamics of autism spectrum disorders. This study assessed the tra...