The process of atresia is an all-or-none phenomenon in that an entire follicle either undergoes atresia or continues along the developmental pathway. The absence of pockets of atresia adjacent to healthy areas of granulosa cells suggests the existence of a coordinating influence within the entire follicular unit during the process of atresia. Gap junctions interconnect the granulosa cells and t...

anti-müllerian hormone (amh) has been observed to decrease with the development of hemorrhagic anovulatory follicles (hafs) in mares. two studies were conducted to evaluate amh concentration in mares with hafs compared to seasonally anoestrous and cyclic mares, and to elucidate changes of amh with the development of luteinised unruptured follicles (lufs). in study 1, amh and progesterone were e...

Macroscopic and histological analyses of the ovarian cycle of Crotaphytus col/aris were conducted during 1971 and 1972. The reproductive season extends from April to late June; examination of ovarian h istosections revealed two distinct sets of corpora lutea, indicating that two clutches of eggs are produced per season. The average clutch size was 6.4. Corpora lutea regress into permanent ovari...

Transcatheter valvulotomy in pulmonary atresia with an intact ventricular septum can be used as a first step to create biventricular circulation and to stimulate further development of the hypoplastic right ventricle. We describe our experience in a case of a neonate with this congenital cardiac defect who underwent successful transcatheter perforation of the atretic pulmonary valve. This repor...

In this study we investigated histopathological changes of mice ovarian tissues following long-term administration of copper sulfate and induction of chronic copper poisoning. The study comprised of three different groups of twenty one mice as follows: The first group (Group 100) which treated by gavage with copper sulfate at a dose of 100 mg kg-1 for 5 weeks. The second group (Group 200), whic...

K N O W L E D G E of the normal quantitative cyclic changes in the ovarian follicular system would be a meaningful aid in assessing the influence of exogenous agents on the ovary. Previous reports on cyclic changes in bovine vesicular follicles (Hammond, 1927: Cole, 1930; McNutt , 1927: Cupps et al., 19,59; Hansel, 1959) were based on gross counts, or study of the largest follicle in isolated s...

The formation of estrogens from C19 steroids is catalyzed by aromatase cytochrome P450 (P450arom), the product of the cyp19 gene. The actions of estrogen include dimorphic anatomical, functional, and behavioral effects on the development of both males and females, considerations that prompted us to examine the consequences of deficiency of aromatase activity in mice. Mice lacking a functional a...

background: nicotine exposure causes impaired fertility and ovarian dysfunction. the aim of this study was to investigate the possible protective role of melatonin, which is known as an antioxidant agent on altered ovarian functions upon nicotine exposure. methods: a total of 32 female adult nmri mice were divided randomly into four groups (n=8). the control group received vehicle, while group ...

background: chlorpromazine (cpz), an antipsychotic drug, is associated with increased risk of sexual dysfunction through increasing prolactin levels. the current study evaluates the effect of cpz-induced hyperprolactinemia on ovarian follicular growth, gonadotropins, and alteration of ovarian source hormones. materials and methods: in this experimental study, animals were divided into four grou...

Primordial follicles from different mammal species can survive and enter the growth phase in vitro but do not develop beyond the primary stage. The hypothesis was that, in sheep, in vitro follicular growth is arrested because of a lack of secretion of GDF9 and/or BMP15. Cortical slices of 0.3–0.5 mm thickness issued from 5to 6-month-old lambs were cultured for 15 days. The pieces were fixed on ...