نتایج جستجو برای: atherosclerotic risk factors
تعداد نتایج: 1773069 فیلتر نتایج به سال:
BACKGROUND Infection with cytomegalovirus (CMV) is considered a risk factor for progression of atherosclerotic disease. Patients with end-stage renal disease (ESRD) display signs of frequent CMV re-activation, which may be caused by the uraemia-associated defect in cellular immunity. The possible contribution of CMV seropositivity to the hugely increased risk for cardiovascular disease in patie...
BACKGROUND Epidemiological studies have demonstrated that hyperfibrinogenemia is an independent risk factor for cerebrovascular atherosclerosis. However, the underlying mechanisms are poorly understood. We studied whether hyperfibrinogenemia could modify the histological composition of atherosclerotic plaque and precipitate carotid thrombosis resulting from rupture of the plaque. METHODS AND ...
Myocardial infarction in the young provides a unique model for the investigation of potential interactions between atherosclerotic and prothrombotic risk factors. Because myocardial infarction reflects atherothrombotic disease, it is important to take into account factors related to atherosclerosis when examining prothrombotic factors as potential determinants of myocardial infarction. In Weste...
Traditional cardiovascular risk (CV) factors based on the Framingham study have been used to estimate the risk of CV events and determine target cholesterol levels for primary prevention. Recently published systematic reviews have, however, demonstrated that the Framingham risk score is limited in certain cohorts and requires adjustment. Indeed, traditional CV risk factors fail to predict the d...
BACKGROUND There have been scant reports on the cumulative effects of atherosclerotic risk factors on steatohepatitis. METHODS We defined cases of steatohepatitis (n = 124) from one health examination center at National Taiwan University Hospital from January to December 2002. We selected controls, matched by age, gender and drinking status. Metabolic syndrome was defined by the modified ATP-...
Initial descriptions of an association between insuli-naemia and both atherosclerotic cardiovascular disease and its risk factors appeared nearly 30 years ago. In 1969, Stout and Vallance-Owen suggested a direct role for insulin in atherogenesis.' Stout recently summarised laboratory studies supporting a direct atherogenic effect of insulin through stimulation of vascular smooth muscle prolifer...
OBJECTIVE Recent studies have identified a major locus for risk for coronary artery disease and myocardial infarction on chromosome 9p21.3. Stroke, in particular, ischemic stroke caused by atherosclerotic disease, shares common mechanisms with myocardial infarction. We investigated whether the 9p21 region contributes to ischemic stroke risk. METHODS In an initial screen, 15 single nucleotide ...
Atherosclerosis is the main cause of cardiovascular disease, and preventing the progression of atherosclerosis is therefore important. However, in atherosclerotic high-risk patients, the conventional management of traditional risk factors is insufficient to prevent the development of atherosclerosis. Recent studies have shown that proinflammatory cytokines, such as interleukin-6 (IL-6), play a ...
Previous studies have indicated that cerebrovascular diseases (CVDs) seem to increase the occurrence of unruptured intracranial aneurysms (UIAs). However, this maybe explained by the fact that CVDs and UIAs share common risk factors, such as hypertension (HT) and smoking. To clarify the impact of atherosclerotic risk factors on cerebral aneurysmal formation, we explored the incidence of UIAs an...
Background and Purpose—We sought to determine risk factors for stroke and stroke type in persons with isolated systolic hypertension (ISH). Methods—We performed proportional hazards analyses of data from the Systolic Hypertension in the Elderly Program, a double-blind, randomized, placebo-controlled trial of 4736 persons aged $60 years with ISH (systolic blood pressure, 160 to 219 mm Hg; diasto...
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