Angiotensin II (Ang II) has diverse effects on the glomerular tuft such as regulation of glomerular hemodynamics and stimulation of mesangial cell growth, and may be one pivotal factor in the progression of renal disease. In order to locally inactivate Ang II, we overexpressed aminopeptidase A (E.C. 3.4.11.7; ATA), a peptidase involved in the conversion of Ang II into angiotensin III, in a mous...

BACKGROUND The high incidence of persistent postconcussion symptoms in service members with combat-related mild traumatic brain injury has prompted research in the use of hyperbaric oxygen (HBO2) for management. OBJECTIVE The effects of HBO2 on persistent postconcussion symptoms in 60 military service members with at least 1 combat-related mild traumatic brain injury were examined in a single...

AIMS Inappropriate shocks have been an important issue post-implantable cardioverter-defibrillator (ICD) implantation. Moreover, inappropriate ICD shocks are associated with increased mortality. The objective of this study was to evaluate the feasibility of catheter ablation therapy for atrial tachyarrhythmias (ATa) responsible for inappropriate ICD shocks. METHODS AND RESULTS Among 108 conse...

The story of how Alma-Ata and Primary Health Care gained the attention of the world’s health leadership must be seen as one of the most intriguing in the history of health and development. The postcolonial years in the developing world saw health care that was largely hospital-based and curative in its orientation, whichmeant, of course, that most people who needed health care had little or no ...

We have been investigating the use of low-cost, commodity components for multi-terabyte SQL Server databases [SQL]. Dubbed storage bricks, these servers are white box PCs containing the largest ATA drives, value-priced AMD or Intel processors, and inexpensive ECC memory. One issue has been the wiring mess, air flow problems, length restrictions, and connector failures created by seven or more p...

Aurintricarboxylic acid (ATA) was found to be a very potent inhibitor of purified rabbit liver phosphofructokinase (PFK), giving 50% inhibition at 0.2 microM. The inhibition was in a manner consistent with interaction at the citrate-inhibitory site of the enzyme. The data suggest that inhibition of PFK by ATA was not due to denaturation of the enzyme or the irreversible binding of inhibitor, si...

ATAs engineered for having an enlarged small binding pocket were applied the synthesis of enantiomerically pure (R)-benzo[1,3]dioxol-5-yl-butylamine, a chiral component human leukocyte elastase inhibitor DMP 777 (L-694,458). Kinetic resolution racemic amine was performed by using L59A variant (S)-selective ATA from Chromobacterium violaceum (Cv-ATA), providing residual (R)-enantiomer in excelle...

Title of thesis: PHYLOGENETIC ANALYSIS OF SWINE INFLUENZA VIRUSES ISOLATED FROM HUMANS IN ALMA-ATA, KAZAKHSTAN. Rangarajan Padmanabhan, Master of Science, 2009. Thesis directed by: Associate Professor Dr.Daniel Perez, Department of Veterinary Medicine, VA-MD Regional College of Veterinary Medicine, The University of Maryland, College Park. Continuous surveillance of influenza becomes important ...

Arbuscular mycorrhiza (AM) is a mutual symbiosis that involves a complex symbiotic interface over which nutrients are exchanged between the plant host and the AM fungus. Dozens of genes in the host are required for the establishment and functioning of the interaction, among them nutrient transporters that mediate the uptake of mineral nutrients delivered by the fungal arbuscules. We have isolat...