To develop a model of chronic experimental asthma in guinea pigs, the animal was forced to inhale the mist of a low dose of ovalbumin (OA) adsorbed on fine Al(OH)3 for sensitization once every 4 weeks. The animal was challenged by inhalation with the mist of OA on day 14 after the respective sensitizations. Either the first or the second antigen challenge markedly induced an early asthmatic res...

Inhalation of cold air is known to induce intrapulmonary airway obstruction in sensitive asthmatic patients and this is a condition often ascribed to heat and water losses from the airway mucosa ( 1-6). However, the pathophysiological mechanism explaining why airway cooling and exercise cause broncho-obstruction is not yet clear. The fact that anticholinergic drugs suppress exercise-induced ast...

INTRODUCTION  The prevalence of asthma has grown considerably in recent decades, but some studies have shown stabilization of this trend. The masticatory process of asthmatic children may be altered due to asthma-related anatomo-functional changes. OBJECTIVE  The study objective was to determine the clinical and electromyographic characteristics of the masticatory process in asthmatic childre...

the aim of this study was to assess the frequency of rhinitis in asthmatic infants. a cross-sectional study was conducted using clinical data obtained from a standardized allergy work-up form that includes specific questions on common allergic diseases. asthmatic patients were seen at the first visit to the pediatric allergy unit, from january 2001 to january 2006, were selected for analysis. d...

BACKGROUND Glucocorticoids (GCs) are the most effective drugs for the treatment of human asthma. However, a subgroup of asthmatic patients with neutrophilic airway inflammation is insensitive to GCs. Interleukin-17 (IL-17), a cytokine upregulated in the airways of a subset of human asthmatic patients, contributes to the recruitment of neutrophils and induces a glucocorticoid resistance in human...

Not all asthmatic patients adequately respond to current available treatments, such as inhaled corticosteroids or omalizumab®. New treatments will aim to target the bronchial epithelium-immune response interaction using different pathways. HLA-G is involved in immunomodulation and may promote epithelial cell differentiation and proliferation. HLA-G protein has several isoforms generated by alte...

the aim of this study was identification of fungi in indoor and outdoor of asthmatic patients´ home environment. opened plates (containing of malt extract agar media) were used for isolation of fungi in the air of indoor (n=360) and outdoor (n=180) of 90 asthmatic patients̉ home living in the city of sari at the level of breathing height. plates were incubated in room temperature for 7-14 days. ...

BACKGROUND Decreased epinephrine (EPI) is an important underlying factor of bronchoconstriction in asthma. Exogenous β(2)-adrenergic receptor agonist is one of the preferred options to treat asthma. We previously showed that this phenomenon involved adrenal medullary chromaffin cell (AMCC) transformation to a neuron phenotype. However, the underlying molecular mechanism is not fully understood....

PURPOSE The purpose of our research was to compare the body mass index (BMI) and selected anthropometric parameters in asthmatic and non-asthmatic pubescents. MATERIAL AND METHODS The study group consisted of 64 asthmatic boys and 45 girls; the control group consisted of 68 nonasthmatic boys and 48 non-asthmatic girls. All the children were 12-14 years old. We measured anthropometric paramete...

Objective: The aim of this investigation was to prepare ODFs containing Naproxen Sodium, an NSAID, using solvent casting method and evaluate them put together a dosage form which can be taken without water, is easy administer, has rapid onset action surmount first pass metabolism. Six distinct formulations naproxen sodium ODF (F1-F6) were created in by varying the quantity croscarmellose sodium...