نتایج جستجو برای: associated neurodegeneration

تعداد نتایج: 1531207  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Emanuela Colla Philippe Coune Ying Liu Olga Pletnikova Juan C Troncoso Takeshi Iwatsubo Bernard L Schneider Michael K Lee

Accumulation of misfolded α-synuclein (αS) is mechanistically linked to neurodegeneration in Parkinson's disease (PD) and other α-synucleinopathies. However, how αS causes neurodegeneration is unresolved. Because cellular accumulation of misfolded proteins can lead to endoplasmic reticulum stress/unfolded protein response (ERS/UPR), chronic ERS could contribute to neurodegeneration in α-synucle...

Objective(s): Epidemiological and biochemical studies conducted over the past two decades have established a strong link between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). However, the exact mechanisms through which aberrations in insulin signaling associated with T2DM contribute to cognitive decline are not yet known. Materials and Methods: In an effort to explore possible m...

2017
Sophie Ayciriex Fathia Djelti Sandro Alves Anne Regazzetti Mathieu Gaudin Jennifer Varin Dominique Langui Ivan Bièche Eloise Hudry Delphine Dargère Patrick Aubourg Nicolas Auzeil Olivier Laprévote Nathalie Cartier

Impairment in cholesterol metabolism is associated with many neurodegenerative disorders including Alzheimer's disease (AD). However, the lipid alterations underlying neurodegeneration and the connection between altered cholesterol levels and AD remains not fully understood. We recently showed that cholesterol accumulation in hippocampal neurons, induced by silencing Cyp46a1 gene expression, le...

Journal: :The Journal of clinical investigation 2012
Zijing Sheng Sugako Oka Daisuke Tsuchimoto Nona Abolhassani Hiroko Nomaru Kunihiko Sakumi Hidetaka Yamada Yusaku Nakabeppu

8-Oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species, is associated with carcinogenesis and neurodegeneration. Although the mechanism by which 8-oxoG causes carcinogenesis is well understood, the mechanism by which it causes neurodegeneration is unknown. Here, we report that neurodegeneration is triggered by MUTYH-mediated excision repair of 8-oxoG-paired adenine. Mutant...

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