نتایج جستجو برای: associated lipocalin

تعداد نتایج: 1521908  

2014
Sukhwinder Kaur Neil Sharma Shiv Ram Krishn Imay Lakshmanan Satyanarayana Rachagani Michael J. Baine Lynette M. Smith Subodh M. Lele Aaron R. Sasson Sushovan Guha Kavita Mallya Judy M. Anderson Michael A. Hollingsworth Surinder K. Batra

Purpose:MUC4 shows aberrant expression in early pancreatic lesions and ahigh specificity for pancreatic cancer. It thushas ahighpotential tobe a sensitive and specific biomarker.Unfortunately, its low serum level limits its diagnostic/prognostic potential.We here report that amultifaceted acute phase protein lipocalin 2, regulated by MUC4, could be a potential diagnostic/prognostic marker for p...

Journal: :The European respiratory journal 2014
Kohei Ikezoe Tomohiro Handa Kiyoshi Mori Kizuku Watanabe Kiminobu Tanizawa Kensaku Aihara Tatsuaki Tsuruyama Aya Miyagawa-Hayashino Akihiko Sokai Takeshi Kubo Shigeo Muro Sonoko Nagai Toyohiro Hirai Kazuo Chin Michiaki Mishima

Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kD lipocalin that is covalently bound to matrix metalloproteinase (MMP)-9 produced by neutrophils [1]. NGAL in blood or bronchoalveolar lavage fluid (BALF) may reflect neutrophilic inflammation in the lungs [2, 3], and it is highly induced in injured epithelial cells, including those in the lung [4]. Possible roles for neutrophilic infla...

2014
Sukhwinder Kaur Neil Sharma Shiv Ram Krishn Imay Lakshmanan Satyanarayana Rachagani Michael J. Baine Lynette M. Smith Subodh M. Lele Aaron R. Sasson Sushovan Guha Kavita Mallya Judy M. Anderson Michael A. Hollingsworth Surinder K. Batra

Purpose:MUC4 shows aberrant expression in early pancreatic lesions and ahigh specificity for pancreatic cancer. It thus has ahighpotential tobe a sensitive and specific biomarker.Unfortunately, its low serum level limits its diagnostic/prognostic potential.We here report that amultifaceted acute phase protein lipocalin 2, regulated by MUC4, could be a potential diagnostic/prognostic marker for ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Sukhwinder Kaur Neil Sharma Shiv Ram Krishn Imay Lakshmanan Satyanarayana Rachagani Michael J Baine Lynette M Smith Subodh M Lele Aaron R Sasson Sushovan Guha Kavita Mallya Judy M Anderson Michael A Hollingsworth Surinder K Batra

PURPOSE MUC4 shows aberrant expression in early pancreatic lesions and a high specificity for pancreatic cancer. It thus has a high potential to be a sensitive and specific biomarker. Unfortunately, its low serum level limits its diagnostic/prognostic potential. We here report that a multifaceted acute phase protein lipocalin 2, regulated by MUC4, could be a potential diagnostic/prognostic mark...

Journal: :American journal of physiology. Endocrinology and metabolism 2008
H C Owen S J Roberts S F Ahmed C Farquharson

Glucocorticoids (GC) are commonly used anti-inflammatory drugs, but long-term use can result in marked growth retardation in children due to their actions on growth plate chondrocytes. To gain an insight into the mechanisms involved in GC-induced growth retardation, we performed Affymetrix microarray analysis of the murine chondrogenic cell line ATDC5, incubated with 10(-6) M dexamethasone (Dex...

Journal: :Journal of pediatric endocrinology & metabolism : JPEM 2012
Ahmet Zulfikar Akelma Ayhan Abaci Osman Ozdemir Aydin Celik Zekai Avci Cem Hasan Razi Samil Hizli Okhan Akin

OBJECTIVE We aimed to evaluate the association between serum lipocalin-2 level and clinical and metabolic parameters in obese children. METHODS The study included obese children with a body mass index (BMI) >95th percentile who presented to Kecioren Teaching and Research Hospital with the complaint of weight gain and healthy children with a BMI <85th percentile. The height and weight of the p...

Abdolrasul Aalaee, Alireza Rafiei, Araz Mohammad Mirabi, Ehsan Abedi , Hamid MohammadJafari, Mohammad Abedi,

Background: Routine diagnostic methods of Vesicoureteral reflux (VUR) are invasive and can cause exposure to radiation and may increase risk of urinary tract infections. Therefore, introducing reliable, non invasive methods might be more interested in pediatric nephrology. The objective of this perspective case control study was to evaluate the prognostic value of urinary neutrophil-gelatinase ...

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