Pleurotus cornucopiae (PC) mushrooms are found in the field and commonly known in Japan as Tamogidake mushrooms. The present study investigated the protective effects of an aqueous extract of PC on carbon tetrachloride (CCl4)-induced hepatotoxicity and the possible mechanism involved in this protection including cytochrome P450 (CYP) 2E1. Wistar rats were pretreated with aqueous extracts of PC ...

“SMAC” (Sequential Multiple Analyzer plus Computer) is a high-speed computer-controlled multitest analyzer. A 20-channel prototype SMAC (glucose, urea nitrogen, creatinine, carbon dioxide content, total bilirubin, calcium, phosphorus, cholesterol, iron, uric acid, chloride, sodium, potassium, total protein, albumin, creatine kinase, alkaline phosphatase, lactate dehydrogenase, and aspartate and...

We produced three batches of a human-serum-based enzyme reference material (ERM) enriched with human aspartate aminotransferase (EC 2.6.1.1), alanine aminotransferase (EC 2.6.1.2), creatine kinase (EC 2.7.3.2), and lactate dehydrogenase (EC 1.1.1.27). The added enzymes were not exhaustively purified; thus the final ERMs contained some enzymes as contaminants, of which only glutamate dehydrogena...

BACKGROUND An association between use of zidovudine and didanosine and a rare but life-threatening syndrome of hepatic steatosis, lactic acidosis, and myopathy has been reported. OBJECTIVE To describe the syndrome of hepatic steatosis, lactic acidosis, and myopathy in four patients taking stavudine. DESIGN Case series. SETTING A community hospital in Washington, D.C., and National Institu...

Cadmium (Cd) is a potentially toxic trace element frequently existed in foods, water, and air, threatening liver function from its continuous bioaccumulation induction of oxidative stress inflammation. However, the hepatotoxicity Cd during puberty remains unclear. In this study, pubertal mice were given cadmium chloride at dose 5.0 mg/kg·bw by gavage, damage was investigated different treatment...

Relevance. Cranioskeletal trauma has the most severe lesions and is accompanied by significant mortality. The impact of comorbidities caused cardiovascular system, in particular diffuse internal organs are not fully investigated under this condition. A common mechanism pathogenesis these pathological processes development cytolytic syndrome.
 Goal study: to determine dynamics markers cytol...

conclusions decreases in the serum levels of liver aminotransferases and cytokines, in both groups, are related to low-calorie diets and exercise, rather than ptx. results the serum levels of liver aminotransferases were significantly reduced at 3 months and at 6 months, compared with baseline, in both groups. the serum levels of il-6 were significantly decreased, in both groups, only at 6 mont...

background: a hypothesis has been presented about the role of serum iron, ferritin and transferrin saturation among patients with non-alcoholic fatty liver disease (nafld) and resistance to insulin (metabolic syndrome [mets]), but there is much controversy. this study aimed at investigating the level of serum iron and demographic characteristics in patients with nafld with or without mets. meth...