Background: Since the 2015 GRAPPA treatment recommendations were published, therapeutic options and management strategies for psoriatic arthritis (PsA) have advanced considerably. Objectives: The goal of update is to develop high quality, evidence-based PsA, including related conditions comorbidities. Methods: rheumatologists, dermatologists patient research partners (PRPs) updated overarching ...

Background Monoclonal antibodies targeting the interleukin (IL)-23p19 subunit are effective in treatment of psoriatic disease but have different molecular attributes that may translate to differences clinical efficacy. Within this class, guselkumab (GUS) is a fully human IgG1 monoclonal antibody with native Fc region, while risankizumab (RIS) humanised mutated region. Binding these therapeutic ...

BackgroundBDC-1001 is a novel ISAC consisting of an investigational trastuzumab biosimilar chemically conjugated to TLR7/8 agonist with non-cleavable linker. BDC-1001 elicits myeloid activation and enhances antigen presentation leading antibody-mediated effector functions that promote T-cell durable adaptive immune response.MethodsA 4-part, phase 1/2 dose-escalation/expansion study was initiate...

Background A higher prevalence of comorbidities, such as obesity, prior treatments, and certain demographics (e.g., age sex) in patients (pts) with psoriatic disease (PsD) may lead to an increased risk adverse events (AEs), sometimes serious [1] . Guselkumab (GUS), a fully human, selective IL-23p19-subunit inhibitor approved treat (tx) adults active arthritis (PsA) moderate severe plaque psoria...

Motivation. Over the past decade, freemium (a combination of free and premium) has become a popular business model, especially among firms that develop information goods such as computer software, online games, applications, and services. In the freemium model, a consumer receives the basic version of a product for free, but can obtain the premium version, which has added features and more func...

Background Tyrosine kinase 2 (TYK2) is an intracellular that mediates signaling of key cytokines (eg, interleukin [IL]-23 and Type I interferons) involved in the pathogenesis immune-mediated diseases including plaque psoriasis psoriatic arthritis (PsA). Deucravacitinib a novel, oral, selective, allosteric inhibitor TYK2 achieves high selectivity by uniquely binding to regulatory domain enzyme, ...

In recent years, we have seen the development of new TEX engines, X E TEX and LuaTEX, adopting OpenType font technology for providing Unicode typesetting support. While there are already plenty of OpenType text fonts available, both from the TEX community and from commercial font suppliers, there is little support for OpenType math fonts so far. Ironically, it was left to Microsoft to develop a...

This article explores the ‘apprehension’ that permeates life in coastal Sierra Leone as fisherfolk struggle to navigate a precarious economy of overfished waters and overstrained relationships. In context deepening uncertainty, social vigilance has come be regarded key survival skill. At sea, even fishermen strain their senses for evidence shoaling fish, they remain equally vigilant rival crews...

Background: XB002 is an antibody-drug conjugate (ADC) composed of a high-affinity tissue factor (TF)-directed human monoclonal antibody conjugated to novel cytotoxic payload, ZymeLink Auristatin. TF, transmembrane protein, functions as FVIIa receptor, initiating the extrinsic coagulation cascade. TF also expressed in multiple tumor types. demonstrated antitumor activity pre-clinical studies acr...