The radical-scavenging activities of two thiols, eight (thio)barbituric acid derivatives and six chain-breaking phenolic antioxidants were investigated using the induction period method for polymerization of methyl methacrylate (MMA) initiated by thermal decomposition of 2,2’-azobisisobutyronitrile (AIBN) and monitored by differential scanning calorimetry (DSC). The induction period (IP) for th...

An efficiently simple protocol for the synthesis of methyl 7 amino-4-oxo-5-phenyl-2-thioxo-2, 3, 4,5-tetrahydro-1H-pyrano[2,3-d]pyrimidine-6-carboxylates via one-pot three component condensation pathway is established via microwave irradiation using varied benzaldehyde derivatives, methylcyanoacetate and thio-barbituric acid in water as a green solvent. A variety of functionalized substrates we...

The present study was designed to investigate the ameliorative potential of Ocimum sanctum and its saponin rich fraction in vincristine-induced peripheral neuropathic pain in rats. Peripheral neuropathy was induced in rats by administration of vincristine sulfate (50 mug/kg i.p.) for 10 consecutive days. The mechanical hyperalgesia, cold allodynia, paw heat hyperalgesia and cold tail hyperalges...

The effect of free radicals on the cell metabolism is well established. Plants are rich natural sources of antioxidants, which are most effective agents to prevent free radical associated adverse cellular interactions. The purpose of this investigation was to find out the free radical scavenging efficacy associated with Colocasia esculenta whole leaf juice. The free radicals were generated usin...

The present study was undertaken to explore the potential of erythropoietin in memory deficits of mice. Memory impairment was produced by scopolamine (0.5 mg/kg, i.p.) and intracerebroventricular streptozotocin (i.c.v STZ, 3 mg/kg, 10 µl, 1(st) and 3(rd) day) in separate groups of animals. Morris water-maze test was employed to assess learning and memory. The levels of brain thio-barbituric aci...

BACKGROUND We assessed indoor air quality in photocopier centers and investigated whether occupational exposure to emissions from photocopiers is associated with decline in lung function or changes in haematological parameters, oxidative stress and inflammatory status. METHODS Indoor air quality was monitored in five photocopier centers. Pulmonary function was assessed by spirometry in 81 pho...

BARBITURIC acid was first synthesized by Conrad and Guthzeit in 1882, and in 1903 the 5:5-diethyl derivative was introduced into medicine as a hypnotic by Carl Fischer and von Mering, under the name of Veronal. In the past, barbituric acid was usually regarded as the cyclic ureide of malonic acid, i.e. as malonyl urea, and its structural formula written in a form which emphasized this relations...

Radiolysis products resulting from the deamination pathway were isolated and identified after irradiation of cytosine by gamma rays in neutral aqueous solutions. They were identical to those identified in uracil radiolysis i. e. 5,6-dihydroxy-5,6-dihydro-uracil (cis and trans forms), iso-dialuric acid, alloxan, 5-hydroxy-hydantoin, parabanic acid and oxaluric acid. The absence of 4,4'-di-iso-ba...