Accumulation of hyperphosphorylated Tau protein as paired helical filaments in pyramidal neurons is a major hallmark of Alzheimer disease. Besides hyperphosphorylation, other modifications of the Tau protein, such as cross-linking, are likely to contribute to the characteristic features of paired helical filaments, including their insolubility and resistance against proteolytic degradation. In ...

The glyoxalation of a methanol-fractionated alkali lignin was executed at 60 °C for 8 h with different amounts of glyoxal (40% in water) and 30% NaOH. The weights of the lignin and water were fixed at 10.0 and 15.0 g, respectively. The gel permeation chromatography (GPC) results indicated that depolymerization of lignin molecules occurred during the glyoxalation process. However, a higher polyd...

Reactions of the aryl complexes Rh(aryl){? 3 -P,O,P-[xant(P i Pr 2 ) ]} (1; = 3,5-Me C 6 H (a), 5 (b), 3,5-Cl (c), 3-FC 4 (d); xant(P 9,9-dimethyl-4,5-bis-(diisopropylphosphino)xanthene) with O , CO, and MeO CC?CCO Me have been performed. Under 1 atm pentane solutions afford dinuclear peroxide derivatives [Rh(aryl){? -P,P-xant(P }] (?-O (2a–2d) as yellow solids. In solution, these species are u...

Product formation in the reaction of perfluorinated methyl vinyl ether, CF3OCF=CF2, with OH radicals is studied theoretically using the M06-2X/aug-cc-pVTZ and CCSD(T) levels of theory. The stable end-products in an oxidative atmosphere are predicted to be perfluorinated methyl formate, CF3OCFO, and fluorinated glycolaldehyde, CFOCF2OH, both with CF2O as coproduct. The prediction of glycolaldehy...

Space-borne observations are used to characterize the fate of formaldehyde and glyoxal in wildfire plumes. Their distribution measured by Tropospheric Monitoring Instrument reveals striking differences between two compounds near intense fires. In typical situations, glyoxal-to-formaldehyde ratio is highest fire (∼0.1) decreases downwind source area due larger contribution pyrogenic emissions ab...

Edible and/or biodegradable films usually have limited water vapor barriers, making it difficult to use them. Thus, the objective of this work was to evaluate the effect of a chemical reticulation treatment with formaldehyde and glyoxal on the mechanical properties, water vapor permeability, solubility and color parameters of gelatin-based films. Formaldehyde and glyoxal were added to the filmo...

The vibrational redistribution of energy following internal conversion in glyoxal has been studied in a molecular beam using the "pump-and-probe" technique. A beam of glyoxal is initially pumped from So to a selected vibronic level of Sl. After internal conversion occurs, a tunable dye laser is used to probe the hot band absorption of the molecules by re-excitation into Sl. The total fluorescen...

Propylglyoxal bis(guanylhydrazone) sulfate, a novel analog of the well-known antileukemic drug methylglyoxal bis(guanylhydrazone), has been prepared from 2,2-dibromopentanal, and the compound has been characterized biochemically. Although it is a powerful inhibitor of S-adenosylmethionine decarboxylase, its Ki value (0.2 microM) is considerably higher than that of ethylglyoxal bis(guanylhydrazo...

For use in screening for environmental mutagens and carcinogens, a highly fluorescent derivative of guanosine, 2'-deoxy-2'-(2",3"-dihydro-2",4"-diphenyl-2"-hydroxy-3"-oxo-1"-pyrrol yl) guanosine (FG), was synthesized. When incubated with FG in aqueous solution, mutagens form adducts that can be analyzed with an HPLC-fluorescence detector-system. By this method, mutagens such as glyoxal, methylg...