objective(s) articular cartilage tissue defects cannot be repaired by the proliferation of resident chondrocytes. autologous chondrocyte transplantation (act) is a relatively new therapeutic approach to cover full thickness articular cartilage defects by in vitro grown chondrocytes from the joint of a patient. therefore, we investigated the redifferentiation capability of human chondrocytes mai...

BACKGROUND Commercially available fibrin is routinely being used as both a matrix in certain cartilage repair techniques and a method for scaffold fixation. Chondrocytes from non-digested particulated cartilage fragments are proposed as a possible source for new cartilage tissue formation in some operative techniques. The goal of this study was to test that chondrocytes from particulated articu...

INTRODUCTION The surgical repair of traumatic tears of the meniscus may enhance tissue remodeling, help to maintain the stability of the knee joint, and prevent osteoarthritic changes. After repair of the experimentally lacerated meniscus, treatment by intra-articular injections of hyaluronan (HA) has been shown to enhance meniscal remodeling [2]. HA treatment also appears to slow the degenerat...

INTRODUCTION: Human articular cartilage degeneration has been strongly associated with aging, the degree of osteoarthritis, as well as levels of biomechanical stress. Morphometric changes in the subchondral plate, chondrocyte density and levels of calcification have been implicated as causes of osteoarthritis, but these relationships remain controversial because of conflicting conclusions. For ...

Articular cartilage is a non-vascularized and poorly cellularized connective tissue that is frequently damaged as a result of trauma and degenerative joint diseases such as osteoarthrtis. Because of the absence of vascularization, articular cartilage has low capacity for spontaneous repair. Today, and despite a large number of preclinical data, no therapy capable of restoring the healthy struct...

The objective was to study the effect of phosphate salts and fixation solutions on the proton dynamics in articular cartilage in vitro. Microscopic magnetic resonance imaging (μMRI) T(2) anisotropy and nuclear magnetic resonance (NMR) double quantum-filtered (DQF) spectroscopy were used to study the full-thickness articular cartilage from several canine humeral heads. The in-plane pixel size ac...

Introduction. The regeneration capacity of cartilage in general is very limited. Cartilage does not contain blood vessels and is thought to consist of only one cell type (chondrocytes) lacking progenitor cells. The chondrocytes, laying isolated in a dense extracellular matrix, have very limited proliferation potential. Despite the absence of repair or regeneration of damaged articular cartilage...

The purpose of this article is to review the current image study of articular cartilage in China, the conventional and new MRI sequences to be used in cartilage, the clinical application of MRI, Our team’s achievements, and future directions and developments in cartilage imaging. In conclusion, articular cartilage plays an important role in the function of the joints of the body. MRI is a nonin...

Objective. Articular cartilage shows changes with age that are considered to be the most important factors in the development and progression of osteoarthritis. The studies on age changes in articular cartilage have been traditionally based on individual observations but this approach is limited by its subjectivity and bias, yielding considerable variability. So the present study was conducted ...

INTRODUCTION Vascular endothelial growth factor (VEGF) is expressed in osteoarthritic articular cartilage. However, the pattern of VEGF expression throughout the whole life cycle of articular cartilage is not well elucidated. The aim of the study was to investigate the spatiotemporal expression of VEGF and its receptors, vascular endothelial growth factor receptor-1 (VEGFR1) and vascular endoth...