There is increasing evidence that chemokines and chemokine receptors are causally involved in tumorigenesis by facilitating tumor proliferation and metastasis. Little is known about the possible function of chemokine receptors in the development and progression of renal cell carcinoma (RCC). We, therefore, analyzed the expression of chemokine receptors in tumor specimens and adjacent healthy ki...

This Article describes and critiques the increasingly popular program of reductive neuroLaw. Law has irrevocably entered the age of neuroscience. Various institutes and conferences are devoted to questions about the relation between neuroscience and legal procedures and doctrines. Most of the new “neuroLaw” scholarship focuses on evidentiary and related issues, and is important and beneficial. ...

The sensitivity of the calculated matter radius to the binding energy is exploited to estimate the 2n binding energy of 22C, using a recent experimental value of Rm=5.4(9) fm. The result is B2n < 220 keV, significantly smaller than another recent estimate. Disciplines Physical Sciences and Mathematics | Physics Comments Fortune, H. T. and Sherr, R. (2012). Binding Energy of 22C. Physical Review...

OBJECTIVE The objective of this article is to discuss the reasons that manuscripts fail to be published and to establish some principles for increasing the likelihood of publication. CONCLUSION Many good manuscripts fail to be published because they violate a few simple rules for writing a superior journal article. This review presents 10 principles for increasing the likelihood of manuscript...

The aim of the current study is to examine the influence of the victim's, perpetrator's, and participant's ethnicity on victim and perpetrator blame attributions. Additionally, comparisons between males and females and a community and student sample were made. Participants read a rape vignette in the form of a newspaper article and subsequently attributed victim and perpetrator blame. A 2 (vict...

The combination of lenvatinib, a multiple receptor tyrosine kinase inhibitor, plus everolimus, a mammalian target of rapamycin (mTOR) inhibitor, significantly improved clinical outcomes versus everolimus monotherapy in a phase II clinical study of metastatic renal cell carcinoma (RCC). We investigated potential mechanisms underlying the antitumor activity of the combination treatment in preclin...

γ-glutamylcysteine synthetase (Gcs) is a vital enzyme catalyzing the first and rate limiting step in the trypanothione biosynthesis pathway, the ATP-dependent ligation of L-Glutamate and L-Cysteine to form gamma-glutamylcysteine. The Trypanothione biosynthesis pathway is unique metabolic pathway essential for trypanosomatid survival rendering Gcs as a potential drug target. Here we report the c...